BIOspektrum

, Volume 22, Issue 2, pp 204–207 | Cite as

Robuste industrielle Bioprozesse: vom Labor- zum Industriemaßstab und zurück

Biotechnologie Bioprozessentwicklung
First Online:

Abstract

Scale-up of bioprocesses remains a challenge and represents a barrier for novel production processes. Feeding of substrate solution by the commonly applied fed-batch mode leads to heterogeneities in the fluid phase in industrial scale bioreactors. This in turn affects the metabolic activity of cells. This article describes the development of scale-down concepts and observed cellular responses under oscillatory cultivation conditions. These present strategies build a basis for improved scaledown approaches.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Fachgebiet Bioverfahrenstechnik, Institut für BiotechnologieTechnische Universität BerlinBerlinDeutschland

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