Advertisement

BIOspektrum

, Volume 21, Issue 7, pp 725–727 | Cite as

Myeloperoxidase – ein neuer Marker zur Erforschung von Entzündungen?

  • Jörg Flemmig
  • Anna Leichsenring
  • Franziska Lange
Wissenschaft · Special: Molekulare Diagnostik Entzündungsmarker
  • 36 Downloads

Abstract

Neutrophilic granulocytes, the most abundant immune cell type in the blood, are essential for the initiation as well as for the regulation and termination of acute inflammatory reactions. Thereby the enzyme myeloperoxidase (MPO) formed by these cells could be a key player. Thus a newly developed method for the quick purification of neutrophilic granulocytes from blood samples and a subsequent activity staining for MPO is presented which may contribute to a better understanding of the (patho-)physiological role of this enzyme.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. [1]
    Arnhold J, Flemmig J (2010) Human myeloperoxidase in innate and acquired immunity. Arch Biochem Biophys 500:92–106CrossRefPubMedGoogle Scholar
  2. [2]
    Odobasic D, Kitching AR, Yang Y et al. (2013) Neutrophil myeloperoxidase regulates T-cell-driven tissue inflammation in mice by inhibiting dendritic cell function. Blood 121:4195–4204CrossRefPubMedGoogle Scholar
  3. [3]
    Flemmig J, Schwarz P, Backer I et al. (2014) Rapid and reliable determination of the halogenating peroxidase activity in blood samples. J Immunol Methods 415:46–56CrossRefPubMedGoogle Scholar
  4. [4]
    Koyani CN, Flemmig J, Malle E et al. (2015) Myeloperoxidase scavenges peroxynitrite: a novel anti-inflammatory action of the heme enzyme. Arch Biochem Biophys 571:1–9PubMedCentralCrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Jörg Flemmig
    • 1
  • Anna Leichsenring
    • 2
  • Franziska Lange
    • 2
  1. 1.Institut für Medizinische Physik und Biophysik, Medizinische FakultätUniversität LeipzigLeipzigDeutschland
  2. 2.Entzündungsmodelle und ImmundiagnostikFraunhofer-Institut für Zelltherapie und Immunologie (IZI)LeipzigDeutschland

Personalised recommendations