Patientenspezifische iPS-Zellen und deren Anwendung in der Herzforschung
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A major research focus in the field of cardiovascular medicine is the prospect of using stem cells for cardiac regeneration. With the advent of induced pluripotent stem cell (iPSC) technology, major efforts are also in process to use iPSCs for modelling heart disease, screening for new drugs, and the development of treatment strategies on a patient-specific level. Here we describe the generation of iPSCs, their efficient differentiation into functional cardiomyocytes, and the power of the iPSC technology for modelling dilative cardiomyopathy on a patient-specific level.
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- Lan ML, Acharya MM, Tran KK et al. (2012) Characterizing the radio response of pluripotent andmultipotent human stem cells. PLoS One 7:e50048Google Scholar