BIOspektrum

, Volume 19, Issue 7, pp 739–741 | Cite as

Transkriptionsregulatoren im Dienste der Biotechnologie

Wissenschaft · Methoden Biosensoren

Abstract

Microbes have evolved a variety of sensor devices for the intracellular detection of small molecules. This capability was recently harnessed for the construction of transcription factor-based biosensors translating the intracellular amino acid accumulation in Corynebacterium glutamicum into a fluorescent readout. These systems were successfully implemented in FACS high throughput screening approaches and allow the study of microbial populations at the single cell level.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Institut für Bio- und Geowissenschaften, IBG-1: BiotechnologieForschungszentrum JülichJülichGermany
  2. 2.Institut für Bio- und Geowissenschaften IBG1: BiotechnologieForschungszentrum JülichJülichGermany

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