Funktionale Zelllinien durch neue Immortalisierungsprotokolle
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Cell lines are immortal cultures of cells that are used in research as well as for production of pharmaceuticals. Currently available cell lines are derived from normal and tumorous tissue of humans and diverse animal species, however, with considerable loss of specific properties. The development of new immortalization protocols has led to a significant improvement of the properties of the resulting cell lines. These retain specific properties and activities that include functional grafting.
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- Botezatu L, Sievers S, Gama-Norton L et al. (2011) Genetic aspects of cell line development from a synthetic biology perspective. Adv Biochem Eng Biotechnol 127:251–284Google Scholar