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BIOspektrum

, Volume 17, Issue 7, pp 736–738 | Cite as

Enzyme am Reißbrett

  • Christoph Malisi
  • André C. Stiel
  • Birte HöckerEmail author
Wissenschaft Proteindesign
  • 64 Downloads

Zusammenfassung

Computergestütztes Design etabliert neue Funktionen auf einem Protein durch theoretisches Sampling des Sequenz- und Konformationsraumes. Wir beschreiben den Ansatz, sein Potenzial sowie die Herausforderungen.

Abstract

Computational design establishes a new functionality on a protein by theoretically sampling its sequence and conformational space. We describe the approach, its potential as well as the challenges ahead.

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Christoph Malisi
    • 1
  • André C. Stiel
    • 1
  • Birte Höcker
    • 1
    • 2
    Email author
  1. 1.AG Protein DesignMax-Planck-Institut für EntwicklungsbiologieTübingenGermany
  2. 2.MPI für EntwicklungsbiologieTübingenGermany

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