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BIOspektrum

, 17:649 | Cite as

Räumliche Organisation bakterieller Zellen

  • Martin Thanbichler
Wissenschaft Zellbiologie
  • 52 Downloads

Zusammenfassung

Bakterien haben komplexe regulatorische Mechanismen entwickelt, um die räumliche Verteilung von zellulären Komponenten zu kontrollieren. Diese werden anhand neuer Ergebnisse zur Positionierung der Zellteilungsebene und Regulation der Morphogenese in Caulobacter crescentus veranschaulicht.

VAAM-Forschungspreis 2011

Abstract

Bacteria have evolved complex regulatory mechanisms to control the spatial distribution of cellular components. This article highlights new findings on division site selection and the regulation of morphogenesis in Caulobacter crescentus that illustrate the underlying principles.

Literatur

  1. [1]
    Thanbichler M, Shapiro L (2008) Getting organized — how bacteria move proteins and DNA. Nat Rev Microbiol 6:28–40PubMedCrossRefGoogle Scholar
  2. [2]
    Shapiro L, McAdams HH, Losick R (2009) Why and how bacteria localize proteins. Science 326:1225–1228PubMedCrossRefGoogle Scholar
  3. [3]
    Thanbichler M (2009) Spatial regulation in Caulobacter crescentus. Curr Opin Microbiol 12:715–721PubMedCrossRefGoogle Scholar
  4. [4]
    Cabeen MT, Jacobs-Wagner C (2010) The bacterial cytoskeleton. Annu Rev Genet 44:365–392PubMedCrossRefGoogle Scholar
  5. [5]
    Lutkenhaus J (2007) Assembly of the bacterial MinCDE system and spatial regulation of the Z ring. Annu Rev Biochem 76:539–562PubMedCrossRefGoogle Scholar
  6. [6]
    Thanbichler M (2010) Synchronization of chromosome dynamics and cell division in bacteria. Cold Spring Harb Perspect Biol 2:a000331PubMedCrossRefGoogle Scholar
  7. [7]
    Viollier PH, Thanbichler M, McGrath PT et al. (2004) Rapid and sequential movement of individual chromosomal loci to specific subcellular locations during bacterial DNA replication. Proc Natl Acad Sci USA 101:9257–9262PubMedCrossRefGoogle Scholar
  8. [8]
    Thanbichler M, Shapiro L (2006) MipZ, a spatial regulator coordinating chromosome segregation with cell division in Caulobacter. Cell 126:147–162PubMedCrossRefGoogle Scholar
  9. [9]
    Möll A, Thanbichler M (2009) FtsN-like proteins are conserved components of the cell division machinery in proteobacteria. Mol Microbiol 72:1037–1053PubMedCrossRefGoogle Scholar
  10. [10]
    Möll A, Schlimpert S, Briegel A et al. (2010) DipM, a new factor required for peptidoglycan remodeling during cell division in Caulobacter crescentus. Mol Microbiol 77:90–107PubMedCrossRefGoogle Scholar
  11. [11]
    Kühn J, Briegel A, Mörschel E et al. (2010) Bactofilins, a ubiquitous class of cytoskeletal proteins mediating polar localization of a cell wall synthase in Caulobacter crescentus. EMBO J 29:327–339PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  1. 1.Universität Marburg und Max-Planck-Institut für Terrestrische MikrobiologieMarburgGermany
  2. 2.Max-Planck-Institut für terrestrische MikrobiologieMarburgGermany

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