BIOspektrum

, Volume 17, Issue 2, pp 158–161 | Cite as

Modellierung G-Protein-gekoppelter Rezeptoren mit ROSETTA

Wissenschaft · Methoden Strukturvorhersage
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Zusammenfassung

Die Verknüpfung funktioneller und struktureller Informationen über G-Protein-gekoppelte Rezeptoren (GPCRs) ist für das Verständnis dieser komplexen Systeme von Vorteil. Wir beschreiben hier die Modellierung von GPCRs mit der Software ROSETTA, wobei auch flexible Regionen abgebildet werden.

Abstract

Combination of functional and structural information of G-protein coupled receptors (GPCRs) aids the understanding of these complex systems. Here we describe modeling of GPCRs using the ROSETTA software suite, which also covers variable regions like loops or termini.

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  1. 1.Institut für BiochemieUniversität LeipzigLeipzigGermany
  2. 2.Center for Structural BiologyVanderbilt UniversityNashvilleUSA
  3. 3.Center for Structural BiologyVanderbilt UniversityNashvilleUSA

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