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Atrial Fibrillation Is Associated with Recurrent Ventricular Arrhythmias After LVAD Implant: Incidence and Impact in a Consecutive Series

  • Kathleen T. Hickey
  • Paolo C. Colombo
  • Yoshifumi Naka
  • Arthur R. Garan
  • Melana Yuzefpolskaya
  • Hasan Garan
  • Elaine Y. Wan
  • Robert R. Sciacca
  • Isaac Goldenthal
  • Angelo B. BivianoEmail author
Original Article

Abstract

This study examined left-ventricular assist device (LVAD) patients with pre-LVAD ventricular arrhythmias (VAs) to determine the rate of recurrent post-LVAD VAs and the impact of pre-LVAD atrial fibrillation (AF) on recurrent post-LVAD VAs. Medical records of 195 consecutive LVAD patients were reviewed. Descriptive statistics were generated and Cox proportional hazard models were used to assess the association of clinical variables with the time to recurrent VA. Forty-seven percent of 195 CHF patients who received LVAD-manifested significant VAs prior to LVAD implant (82% Heartmate II, 14% HVAD, 4% other; median follow-up = 17 months), 41% of whom manifested recurrent post-LVAD VAs. Pre-LVAD AF was associated with recurrent VAs (hazard ratio = 3.73; 95% CI 1.33, 10.48; p = 0.012). Recurrent VAs were associated with increased mortality (hazard ratio = 3.06; 95% CI 1.17, 7.98; p = 0.023). A history of AF is prevalent in over half of LVAD patients with recurrent VAs and is associated with time to recurrence of VA.

Keywords

Ventricular arrhythmias Left ventricular assist devices Cardiac outcomes Atrial fibrillation 

Notes

Acknowledgments

We would like to acknowledge our research coordinator Paul Gonzalez, who assisted with the data collection.

Compliance with Ethical Standards

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee (Columbia University IRB-AAAM2607) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Conflict of Interest

The authors declare that they have no conflicts of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Kathleen T. Hickey
    • 1
  • Paolo C. Colombo
    • 2
  • Yoshifumi Naka
    • 2
  • Arthur R. Garan
    • 2
  • Melana Yuzefpolskaya
    • 2
  • Hasan Garan
    • 2
  • Elaine Y. Wan
    • 2
  • Robert R. Sciacca
    • 1
  • Isaac Goldenthal
    • 2
  • Angelo B. Biviano
    • 2
    Email author
  1. 1.Columbia University School of NursingNew YorkUSA
  2. 2.Columbia University Irving Medical CenterNew YorkUSA

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