New Insights into the Role of Exosomes in the Heart After Myocardial Infarction

  • Na LiEmail author
  • Luc Rochette
  • Yongxin Wu
  • Nathalie Rosenblatt-Velin


Intercellular communications play a pivotal role in several cardiac pathophysiological processes. One subtype of extracellular vesicles, so-called exosomes, became known as important intercellular communication mediators in the heart. Exosomes are lipid bilayer biological nanovesicles loaded with diverse proteins, lipids, and mRNAs/microRNAs. All major cardiac cell types can modulate recipient cellular function via the release of exosomes. After myocardial infarction (MI), exosomes, especially those secreted by different cardiac stem cells, have been shown to confer cardioprotective effects, activate regenerative signals, and participate into cardiac repair. In this review, we rapidly recall the biology of exosomes at the beginning. Then we summarize the exosomes secreted by different myocardial cells and their function in cardiac intercellular communication. At last, we discuss the role of these vesicles in cardiac repair after MI.


Exosomes Cardiac cells Myocardial infarction Stem cell therapy 





Cardiac progenitor cells


Cardiospheres-derived cells


Endothelial cells


Extracellular vesicles


Embryonic stem cells


Early endosomes




Intraluminal vesicles


Induced pluripotent stem cells


Late endosomes


Multivesicular bodies




Myocardial infarction


Mesenchymal stem cells


Smooth muscle cells


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflicts of interest.

Ethical Approval

This review article does not contain any studies with human participants or animals performed by any of the authors.


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Unité de Physiopathologie Clinique, Département cœur-vaisseauxCentre Hospitalier Universitaire Vaudois and University of LausanneLausanneSwitzerland
  2. 2.Research team Pathophysiology and Epidemiology of Cerebro-Cardiovascular diseases (PEC2, EA7460)University of Bourgogne Franche-ComtéDijonFrance
  3. 3.FEMTO-ST InstituteUniversity of Bourgogne Franche-ComtéBesançonFrance

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