Severity of Hypertension Correlates with Risk of Thromboembolic Stroke
Hypertension plays a significant role in the development of atrial fibrillation (AF) and its complications. The coexistence of the two diseases increases the risk of thromboembolism events. Although CHADS2 and CHA2DS2-VASc scores have been used in the evaluation of the thromboembolism events in AF patients, the different levels of the blood pressure are not appropriately recognized. In this study, the 970 AF patients were divided into three groups according to the severity of hypertension. The CHADS2 and CHA2DS2-VASc scores in the patients of grade 3 hypertension were significantly higher than those of the patients with grade 1 and 2 hypertension, respectively (P < 0.05). Both the CHADS2 and CHA2DS2-VASc scores were positively related to the severity of hypertension (P < 0.001). Our data demonstrated that three grades for hypertensive subjects with AF significantly improved antithrombotic risk stratification in addition to current clinical risk stratification models, such as CHADS2 and CHA2DS2-VASc scores.
KeywordsAtrial fibrillation Hypertension CHADS2 score CHA2DS2-VASc score
Compliance with Ethical Standards
Sources of Funding
This research was supported by Jiangsu Provincial Medical Youth Talent (QNRC2016383) and Xuzhou Municipal Bureau of Science and Technology (KC16SH042).
Conflict of Interest
The authors declare that they have no competing interests.
Human Subjects/Informed Consent Statement
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration, as revised in 2000. Informed consent was obtained from all individual participants included in the study.
No animal studies were carried out by the authors for this article.
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