Gene Expression Signatures and the Spectrum of Coronary Artery Disease

  • Kevin A. Friede
  • Geoffrey S. Ginsburg
  • Deepak VooraEmail author


Over the past 10–15 years, developments in gene expression profiling have opened new arenas for the discovery of important factors in the pathogenesis of numerous disease processes, including coronary artery disease. Messenger RNA and microRNA are differentially expressed in patients with coronary plaques, acute plaque rupture, and response to well-established treatments for acute coronary syndromes. In this review, we will explore recent developments in messenger RNA and microRNA technology at each stage of a patient’s progression through the natural history of cardiovascular disease, including evaluation of risk factors, prediction and detection of coronary artery disease and acute coronary syndromes, and finally, response to treatments for coronary artery disease and its sequelae including congestive heart failure.


Gene expression profiling mRNA MicroRNA Coronary artery disease 



Angiotensin-converting enzyme


Angiotensin receptor blocker


Cardiovascular disease


Coronary artery disease


Congestive heart failure


Copy number variation


Cytochrome P450


Implantable cardioverter-defibrillator


c-Jun N-terminal kinase


Left anterior descending coronary artery


Major adverse cardiac events




Myocardial infarction


Messenger RNA


Non-ST-elevation myocardial infarction


Peripheral blood mononuclear cell


Receiver operating characteristic


Single nucleotide polymorphism


ST-elevation myocardial infarction


Unstable angina


Compliance with Ethical Standards


This review article did not receive any outside funding.

Conflict of Interest

Drs. Friede, Ginsburg, and Voora each declare that they no conflict of interest.

Ethical Approval

This article does not contain any studies with human participants performed by any of the authors.


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Kevin A. Friede
    • 1
  • Geoffrey S. Ginsburg
    • 1
    • 2
  • Deepak Voora
    • 1
    • 2
    Email author
  1. 1.Department of MedicineDuke UniversityDurhamUSA
  2. 2.Center for Applied Genomics & Precision MedicineDuke UniversityDurhamUSA

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