Pre-clinical In Vitro and In Vivo Models for Heart Valve Therapies

  • Maurizio Taramasso
  • Maximilian Y. Emmert
  • Diana Reser
  • Andrea Guidotti
  • Nikola Cesarovic
  • Marino Campagnol
  • Alessandro Addis
  • Fabian Nietlispach
  • Simon P. Hoerstrup
  • Francesco Maisano
Article
First Online:
Received:
Accepted:

Abstract

Heart valve disease is a frequently encountered pathology, related to high morbidity and mortality rates. Animal models are interesting to investigate the causality but also underlying mechanisms and potential treatments of human heart valve diseases. Strongly believing that both in vivo and ex vivo models are fundamental to support research and development of new technologies, we here report some examples of heart valve disease models, which in our experience have been actively used to support the development of new valve therapies.

Keywords

Heart valve disease Animal models Bench model 
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Notes

Compliance with Ethical Standards

All applicable international, national, and institutional guidelines for the care and use of animals were followed. All procedures performed were in accordance with the ethical standards of the institution or practice at which the studies were conducted.

Conflict of Interest

The authors declare that they have no competing interests.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Maurizio Taramasso
    • 1
  • Maximilian Y. Emmert
    • 1
    • 2
  • Diana Reser
    • 1
  • Andrea Guidotti
    • 1
  • Nikola Cesarovic
    • 2
  • Marino Campagnol
    • 3
  • Alessandro Addis
    • 3
  • Fabian Nietlispach
    • 4
  • Simon P. Hoerstrup
    • 2
  • Francesco Maisano
    • 1
    • 5
  1. 1.Department of Cardiovascular SurgeryUniversity Hospital of ZürichZürichSwitzerland
  2. 2.Division of Surgical ResearchUniversity Hospital of ZürichZürichSwitzerland
  3. 3.Biotech Research Centre for Cardiothoracic Applications CRABCCRivolta d’AddaItaly
  4. 4.Department of CardiologyUniversity Hospital of ZürichZürichSwitzerland
  5. 5.Klinik fur Herz- und GefässchirurgieUniversitätsspital ZurichZurichSwitzerland

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