Application of Adipose-Derived Stem Cells in Heart Disease

  • Lina Chen
  • Fengming Qin
  • Menghua Ge
  • Qiang Shu
  • Jianguo Xu
Article
First Online:
Received:
Accepted:

Abstract

Therapy with mesenchymal stem cells is one of the promising tools to improve outcomes after myocardial infarction. Adipose-derived stem cells (ASCs) are an ideal source of mesenchymal stem cells due to their abundance and ease of preparation. Studies in animal models of myocardial infarction have demonstrated the ability of injected ASCs to engraft and differentiate into cardiomyocytes and vasculature cells. ASCs secrete a wide array of angiogenic and anti-apoptotic paracrine factors such as vascular endothelial growth factor, hepatocyte growth factor, and insulin-like growth factor 1. ASCs are capable of enhancing heart function, reducing myocardial infarction, promoting vascularization, and reversing remodeling in the ischemically injured hearts. Furthermore, several ongoing clinical trials using ASCs are producing promising results for heart diseases. This article reviews the isolation, differentiation, immunoregulatory properties, mechanisms of action, animal models, and ongoing clinical trials of ASCs for cardiac disease.

Keywords

Adipose-derived stem cells Heart disease Myocardial infarction Mesenchymal stem cells 

Abbreviations

ASCs

Adipose-derived stem cells

MI

Myocardial infarction

MSCs

Mesenchymal stem cells

BM

Bone marrow

SVF

Stromal vascular fraction

VEGF

Vascular endothelial growth factor

COX-2

Cyclooxygenase-2

PGE-2

Prostaglandin E2

HGF

Hepatocyte growth factor

Tregs

Regulatory T cells

GVHD

Graft-versus-host disease

IGF-I

Insulin-like growth factor 1

eNOS

Endothelial nitric oxide synthase

ADRCs

Adipose-derived stem and regenerative cells

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Notes

Funding

This work was supported by the National Natural Science Foundation of China (81270068), Zhejiang Health Bureau Cultivation Plan (2014PYA020), and Shaoxing 330 Plan to JX and the National Natural Science Foundation of China (81272139) and the National Science and Technology Support Program (2012BAI04B05) to QS.

Conflict of Interest

The authors declare that they have no competing interests.

Supplementary material

12265_2014_9585_MOESM1_ESM.docx (10 kb)
ESM 1 (DOCX 10 kb)

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Lina Chen
    • 1
  • Fengming Qin
    • 1
  • Menghua Ge
    • 1
  • Qiang Shu
    • 2
  • Jianguo Xu
    • 1
    • 3
    • 4
  1. 1.Shaoxing Second HospitalShaoxingChina
  2. 2.Children’s HospitalZhejiang UniversityShaoxingChina
  3. 3.First Affiliated HospitalZhejiang UniversityShaoxingChina
  4. 4.Shaoxing Second HospitalZhejiang UniversityShaoxingChina

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