Targeting Inflammation: Impact on Atherothrombosis

  • Maria Giulia Marini
  • Chiara Sonnino
  • Marco Previtero
  • Luigi M. Biasucci
Article

Abstract

Atherothrombosis is a worldwide epidemic accounting for an unacceptable toll of deaths and disabilities. Its pathophysiology is complex and hardly referable to a specific mechanism; however, in the last 20 years, a growing amount of evidence has demonstrated that inflammatory processes play a major role from the very beginning to the ultimate complication of atherothrombosis. These evidences are addressing a growing interest toward anti-inflammatory agents as preventive or curative treatments of atherothrombosis. At present, accumulated data are not conclusive, but strong evidence exists in favor of an anti-inflammatory positive effect for several drugs as statins or renin–angiotensin inhibitors. More conclusive data are expected from ongoing trials directly exploring the role of specific cytokines antagonists.

Keywords

Inflammation Atherothrombosis Acute coronary syndrome Anti-inflammatory drugs 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Maria Giulia Marini
    • 1
  • Chiara Sonnino
    • 1
  • Marco Previtero
    • 1
  • Luigi M. Biasucci
    • 1
  1. 1.Institute of CardiologyCatholic UniversityRomeItaly

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