Endothelial Dysfunction and Cardiac Allograft Vasculopathy

  • Monica Colvin-Adams
  • Nonyelum Harcourt
  • Daniel Duprez
Article

Abstract

Cardiac allograft vasculopathy remains a major challenge to long-term survival after heart transplantation. Endothelial injury and dysfunction, as a result of multifactorial immunologic and nonimmunologic insults in the donor and the recipient, are prevalent early after transplant and may be precursors to overt cardiac allograft vasculopathy. Current strategies for managing cardiac allograft vasculopathy, however, rely on the identification and treatment of established disease. Improved understanding of mechanisms leading to endothelial dysfunction in heart transplant recipients may provide the foundation for the development of sensitive screening techniques and preventive therapies.

Keywords

Heart transplant Endothelial function Peripheral artery function Transplant vasculopathy 

Abbreviations

ACE-I

Angiotensin converting enzyme inhibitor

ARB

Angiotensin receptor blocker

cGMP

Cyclic guanosine monophosphate

eNOS

Endothelial nitric oxide synthase

GTP

Guanosine triphosphate

iNOS

Inducible nitric oxide synthase

NO

Nitric oxide

PDE-5

Phosphodiesterase type 5

Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Monica Colvin-Adams
    • 1
    • 2
  • Nonyelum Harcourt
    • 1
    • 3
  • Daniel Duprez
    • 1
    • 4
  1. 1.Cardiovascular DivisionUniversity of MinnesotaMinneapolisUSA
  2. 2.Cardiovascular Division, Advanced Heart Failure and Transplantation SectionUniversity of MinnesotaMinneapolisUSA
  3. 3.Lillehei Clinical Research Unit, Cardiovascular DivisionUniversity of MinnesotaMinneapolisUSA
  4. 4.Cardiovascular Division, Section on PreventionUniversity of MinnesotaMinneapolisUSA

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