Strategies for Tissue Engineering Cardiac Constructs to Affect Functional Repair Following Myocardial Infarction



Tissue-engineered cardiac constructs are a high potential therapy for treating myocardial infarction. These therapies have the ability to regenerate or recreate functional myocardium following the infarction, restoring some of the lost function of the heart and thereby preventing congestive heart failure. Three key factors to consider when developing engineered myocardial tissue include the cell source, the choice of scaffold, and the use of biomimetic culture conditions. This review details the various biomaterials and scaffold types that have been used to generate engineered myocardial tissues as well as a number of different methods used for the fabrication and culture of these constructs. Specific bioreactor design considerations for creating myocardial tissue equivalents in vitro, such as oxygen and nutrient delivery as well as physical stimulation, are also discussed. Lastly, a brief overview of some of the in vivo studies that have been conducted to date and their assessment of the functional benefit in repairing the injured heart with engineered myocardial tissue is provided.


Tissue engineering Myocardial infarction Biomaterials Bioreactor Heart failure Polymer scaffolds 



Myocardial infarction


Extracellular matrix


US Food and Drug Administration


Small intestinal submucosa


Urinary bladder matrix




Poly(lactic-co-glycolic acid)




Poly(trimethylene carbonate-co-lactide)


Vascular endothelial growth factor


Polyethylene glycol


Focal adhesion Kinase


Ras homolog gene family, member A


Arteriovenous blood vessel loop


Fractional shortening


Left ventricular ejection fraction


Engineered heart tissue


Left ventricular end-diastolic dimension


Left ventricular end-diastolic volume


Basic fibroblast growth factor


Cardiac progenitor cells


Insulin-like growth factor 1


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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Biomedical EngineeringTufts UniversityMedfordUSA

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