Human ESC vs. iPSC—Pros and Cons

  • Jane J. Pappas
  • Phillip C. Yang
Innovation, Translation, Education

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Human ESC vs. iPSC—Pros and Cons

Jane J. Pappas · Phillip C.Yang


Recent breakthroughs in stem cell research [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11] have allowed the scientific community to envision a future in which cell-based therapies may become a reality. Most prominent are the reports of pluripotent stem cell inductions from mouse [5, 7] and human [6, 9] somatic cells by defined factors. These findings showcased the feasibility of using terminally differentiated, autologous, patient- and disease-specific cell sources for the derivation of the many differentiated cell types currently sought by the field of regenerative medicine.

From a clinical perspective, tapping into an autologous cell source represents a means to assure blood type and human leukocyte antigen (HLA) group...



The authors wish to thank James Byrne, Ph.D. (Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Palo Alto, CA) and Zeina Saikali, Ph.D. (Juravinski Cancer Centre, Hamilton, Ontario, Canada), for having kindly reviewed the manuscript. The authors also wish to thank Kathleen Gallagher and Brian Habekoss, for having provided excellent administrative support.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Stanford University School of MedicineStanfordUSA

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