Gut Microbiota and Short Chain Fatty Acids: Influence on the Autonomic Nervous System

  • Jessica Bruning
  • Andrew Chapp
  • Gregory A. Kaurala
  • Renjun Wang
  • Stephen Techtmann
  • Qing-Hui ChenEmail author

Reaching across multiple fields of focus, spanning from periodontistry to gastroenterology to neurobiology to behavior, interest in the influence of the microbiome in human physiology and pathology has risen over the past few decades. Microbiota co-exist in and on humans forming an evolutionarily symbiotic biological unit, a halobiont, in which disruptions in the relationship can occur through genomic alterations and mutations [1]. The human microbiome consists of bacteria, viruses, fungi, and protozoans that contribute 450 times more genes to this relationship and slightly outnumber human host cells [2, 3]. The bacteria in the gastrointestinal (GI) tract are of the most interest and exist within five phyla: Bacteroidetes, Firmicutes, Proteobacteria, Actinobacteria, and Verrucomicrobia. Within the Verrucomicrobia an interesting bacterium has emerged, Akkermansia muciniphila, a mucus-degrading bacterium that influences intestinal permeability [3, 4]. The composition of individual...



This insight was supported by Michigan Technological University Portage Health Foundation, America Heart Association (16PRE27780121) and National Natural Science Foundation of China (31871150).

Conflict of interest

The authors declare that they have no conflict of interest.


  1. 1.
    Galla S, Chakraborty Mell B, Vijay-Kumar M, Joe B. Microbiota-host interactions and hypertension. Physiology (Bethesda) 2017, 32: 224–233.Google Scholar
  2. 2.
    Adnan S, Nelson JW, Ajami NJ, Venna VR, Petrosino JF, Bryan RM Jr, et al. Alterations in gut microbiota can elicit hypertension in rats. Physiol Genomics 2016, 49: 96–104.CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Yang T, Santisteban MM, Rodriguez V, Li E, Ahmari N, Carvajal JM, et al. Gut dysbiosis is linked to hypertension. Hypertension 2015, 65: 1331–1340.CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Unger MM, Spiegel J, Dillmann KU, Grundmann D, Philippeit H, Bürmann J, et al. Short chain fatty acids and gut microbiota differ between patients with Parkinson’s disease and age-matched controls. Parkinsonism Relat Disord 2016, 32: 66–72.CrossRefPubMedGoogle Scholar
  5. 5.
    Santisteban MM, Qi Y, Zubcevic J, Kim S, Yang T, Shenoy V, et al. Hypertension-linked pathophysiological alterations in the gut. Circ Res 2017, 120: 312–323.CrossRefPubMedGoogle Scholar
  6. 6.
    Sampson TR, Debelius JW, Thron T, Janssen S, Shastri GG, Ilhan ZE, et al. Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson’s disease. Cell 2016, 167: 1469–1480.CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Perry RJ, Peng L, Barry NA, Cline GW, Zhang D, Cardone RL, et al. Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome. Nature 2016, 534: 213–217.CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Pluznick J. A novel SCFA receptor, the microbiota, and blood pressure regulation. Gut Microbes 2014, 5: 202–207.CrossRefPubMedGoogle Scholar
  9. 9.
    Lal S, Kirkup AJ, Brunsden AM, Thompson DG, Grundy D. Vagal afferent responses to fatty acids of different chain length in the rat. Am J Physiol Gastrointest Liver Physiol 2001, 281: G907– G915.CrossRefPubMedGoogle Scholar
  10. 10.
    Soret R, Chevalier J, De Coppet P, Poupeau G, Derkinderen P, Segain JP, et al. Short-chain fatty acids regulate the enteric neurons and control gastrointestinal motility in rats. Gastroenterology 2010, 138: 1772–1782.CrossRefPubMedGoogle Scholar
  11. 11.
    Chapp AD, Gui L, Huber MJ, Liu J, Larson RA, Zhu J, et al. Sympathoexcitation and pressor responses induced by ethanol in the central nucleus of amygdala involves activation of NMDA receptors in rats. Am J Physiol Heart Circ Physiol 2014, 307: H701– H709.CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Chapp AD, Behnke JE, Driscoll KM, Fan Y, Hoban E, Shan Z, et al. Acetate mediates alcohol excitotoxicity in dopaminergic-like PC12 cells. ACS Chem Neurosci 2019, 10: 235–245.CrossRefPubMedGoogle Scholar

Copyright information

© Shanghai Institutes for Biological Sciences, CAS 2019

Authors and Affiliations

  • Jessica Bruning
    • 1
  • Andrew Chapp
    • 2
  • Gregory A. Kaurala
    • 3
  • Renjun Wang
    • 4
  • Stephen Techtmann
    • 3
  • Qing-Hui Chen
    • 1
    Email author
  1. 1.Department of Kinesiology and Integrative PhysiologyMichigan Technological UniversityHoughtonUSA
  2. 2.Department of NeuroscienceUniversity of MinnesotaMinneapolisUSA
  3. 3.Department of Biological ScienceMichigan Technological UniversityHoughtonUSA
  4. 4.Department of Biotechnology, School of Life ScienceJilin Normal UniversitySipingChina

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