Skip to main content

Advertisement

SpringerLink
Log in

Gut Microbiota and Short Chain Fatty Acids: Influence on the Autonomic Nervous System

  • Insight
  • Published:
Neuroscience Bulletin Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Galla S, Chakraborty Mell B, Vijay-Kumar M, Joe B. Microbiota-host interactions and hypertension. Physiology (Bethesda) 2017, 32: 224–233.

    CAS  Google Scholar 

  2. Adnan S, Nelson JW, Ajami NJ, Venna VR, Petrosino JF, Bryan RM Jr, et al. Alterations in gut microbiota can elicit hypertension in rats. Physiol Genomics 2016, 49: 96–104.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Yang T, Santisteban MM, Rodriguez V, Li E, Ahmari N, Carvajal JM, et al. Gut dysbiosis is linked to hypertension. Hypertension 2015, 65: 1331–1340.

    Article  CAS  PubMed  Google Scholar 

  4. Unger MM, Spiegel J, Dillmann KU, Grundmann D, Philippeit H, Bürmann J, et al. Short chain fatty acids and gut microbiota differ between patients with Parkinson’s disease and age-matched controls. Parkinsonism Relat Disord 2016, 32: 66–72.

    Article  PubMed  Google Scholar 

  5. Santisteban MM, Qi Y, Zubcevic J, Kim S, Yang T, Shenoy V, et al. Hypertension-linked pathophysiological alterations in the gut. Circ Res 2017, 120: 312–323.

    Article  CAS  PubMed  Google Scholar 

  6. Sampson TR, Debelius JW, Thron T, Janssen S, Shastri GG, Ilhan ZE, et al. Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson’s disease. Cell 2016, 167: 1469–1480.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Perry RJ, Peng L, Barry NA, Cline GW, Zhang D, Cardone RL, et al. Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome. Nature 2016, 534: 213–217.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Pluznick J. A novel SCFA receptor, the microbiota, and blood pressure regulation. Gut Microbes 2014, 5: 202–207.

    Article  PubMed  Google Scholar 

  9. Lal S, Kirkup AJ, Brunsden AM, Thompson DG, Grundy D. Vagal afferent responses to fatty acids of different chain length in the rat. Am J Physiol Gastrointest Liver Physiol 2001, 281: G907– G915.

    Article  CAS  PubMed  Google Scholar 

  10. Soret R, Chevalier J, De Coppet P, Poupeau G, Derkinderen P, Segain JP, et al. Short-chain fatty acids regulate the enteric neurons and control gastrointestinal motility in rats. Gastroenterology 2010, 138: 1772–1782.

    Article  CAS  PubMed  Google Scholar 

  11. Chapp AD, Gui L, Huber MJ, Liu J, Larson RA, Zhu J, et al. Sympathoexcitation and pressor responses induced by ethanol in the central nucleus of amygdala involves activation of NMDA receptors in rats. Am J Physiol Heart Circ Physiol 2014, 307: H701– H709.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Chapp AD, Behnke JE, Driscoll KM, Fan Y, Hoban E, Shan Z, et al. Acetate mediates alcohol excitotoxicity in dopaminergic-like PC12 cells. ACS Chem Neurosci 2019, 10: 235–245.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

This insight was supported by Michigan Technological University Portage Health Foundation, America Heart Association (16PRE27780121) and National Natural Science Foundation of China (31871150).

Author information

Authors and Affiliations

  1. Department of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, MI, 49931, USA

    Jessica Bruning & Qing-Hui Chen

  2. Department of Neuroscience, University of Minnesota, Minneapolis, MN, 55455, USA

    Andrew Chapp

  3. Department of Biological Science, Michigan Technological University, Houghton, MI, 49931, USA

    Gregory A. Kaurala & Stephen Techtmann

  4. Department of Biotechnology, School of Life Science, Jilin Normal University, Siping, 136000, Jilin, China

    Renjun Wang

Authors
  1. Jessica Bruning
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Andrew Chapp
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Gregory A. Kaurala
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Renjun Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Stephen Techtmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Qing-Hui Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Qing-Hui Chen.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bruning, J., Chapp, A., Kaurala, G.A. et al. Gut Microbiota and Short Chain Fatty Acids: Influence on the Autonomic Nervous System. Neurosci. Bull. 36, 91–95 (2020). https://doi.org/10.1007/s12264-019-00410-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12264-019-00410-8

Search

Navigation