Pros and Cons: Autophagy in Acute Spinal Cord Injury
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Autophagy plays an important role in the development and pathogenesis of various diseases. It can be induced by a variety of events such as hypoxia, nutrient-starvation, and mechanical damage. Many neurological disorders such Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, Huntington’s disease, cerebral ischemia, and acute spinal cord injury (ASCI), are closely related to autophagy. However, therapeutic strategies to manipulate autophagy have not yet been fully deciphered due to the limited knowledge of the molecular mechanisms underlying autophagy in these disorders.
ASCI is a severe condition characterized by major disability and poor prognosis. Due to the fact that pathological processes of secondary injury in ASCI usually last for several days or even months, the study and treatment of this disease have mainly focused on reducing the progression. Animal studies have shown that rat models with different degrees of contusion in the lower thoracic spinal cord...
This insight was supported by the National Natural Science Foundation of China (81301047).
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