Selective Targeting of Perirhinal Cortex Projection to Hippocampal CA1 Interneurons

  • Xiang Li
  • Yiding Li
  • Junhui ZhangEmail author
  • Xiaohui ZhangEmail author
Letter to the Editor

Dear Editor,

The perirhinal cortex (PER) is conceptually important in the recognition memory, especially in familiarity discrimination, whereas the hippocampus is important for association and recollection [1]. This notion is known as the dual-process model of recognition memory. An alternative idea suggests that, like the hippocampus, the PER contributes to both familiarity and recollection [2], known for the unitary process model. Both models have made strong emphasis on a vital role of the PER and hippocampus in recognition memory, suggesting that they are highly interconnected. Indeed, previous animal studies using anterograde and retrograde tracers revealed direct anatomic projections from the PER to hippocampus in rodents and monkeys [3, 4, 5]. However, the latter projection is less prominent compared to that of PER to entorhinal cortex (EC) or that of EC to hippocampus. This may implicate that information flow from PER to hippocampus is primarily through an indirect path, where...



This work was supported by grants from the Beijing Municipal Science & Technology Commission (Z181100001518001) and the Interdisciplinary Research Funds of Beijing Normal University.

Supplementary material

12264_2019_363_MOESM1_ESM.pdf (529 kb)
Supplementary material 1 (PDF 529 kb)


  1. 1.
    Brown MW, Aggleton JP. Recognition memory: what are the roles of the perirhinal cortex and hippocampus? Nat Rev Neurosci 2001, 2: 51–61.CrossRefGoogle Scholar
  2. 2.
    Suzuki WA, Naya Y. The perirhinal cortex. Annu Rev Neurosci 2014, 37: 39–53.CrossRefGoogle Scholar
  3. 3.
    Witter MP, Groenewegen HJ, Lopes da Silva FH, Lohman AH. Functional organization of the extrinsic and intrinsic circuitry of the parahippocampal region. Prog Neurobiol 1989, 33: 161–253.Google Scholar
  4. 4.
    Burwell RD, Witter MP, Amaral DG. Perirhinal and postrhinal cortices of the rat: a review of the neuroanatomical literature and comparison with findings from the monkey brain. Hippocampus 1995, 5: 390–408.CrossRefGoogle Scholar
  5. 5.
    Lavenex P, Amaral DG. Hippocampal-neocortical interaction: a hierarchy of associativity. Hippocampus 2000, 10: 420–430.CrossRefGoogle Scholar
  6. 6.
    Burwell RD, Amaral DG. Perirhinal and postrhinal cortices of the rat: Interconnectivity and connections with the entorhinal cortex. J Compar Neurol 1998, 391: 293–321.CrossRefGoogle Scholar
  7. 7.
    Canning KJ, Leung LS. Lateral entorhinal, perirhinal, and amygdala-entorhinal transition projections to hippocampal CA1 and dentate gyrus in the rat: a current source density study. Hippocampus 1997, 7: 643–655.CrossRefGoogle Scholar
  8. 8.
    Naber PA, Witter MP, Lopez da Silva, FH. Perirhinal cortex input to the hippocampus in the rat: evidence for parallel pathways, both direct and indirect. A combined physiological and anatomical study. Eur J Neurosci 1999, 11: 4119–4133.Google Scholar
  9. 9.
    Petreanu L, Mao T, Sternson SM, Svoboda K. The subcellular organization of neocortical excitatory connections. Nature 2009, 457: 1142–1145.CrossRefGoogle Scholar
  10. 10.
    Li YD, Xu JM, Liu YF, Zhu J, Liu N, Zeng WB, et al. A distinct entorhinal cortex to hippocampal CA1 direct circuit for olfactory associative learning. Nat Neurosci 2017, 20: 559–570.CrossRefGoogle Scholar
  11. 11.
    Freund TF, Buzsaki G. Interneurons of the hippocampus. Hippocampus 1996, 6: 347–470.CrossRefGoogle Scholar
  12. 12.
    Furtak SC, Wei SM, Agster KL, Burwell RD. Functional neuroanatomy of the parahippocampal region in the rat: The perirhinal and postrhinal cortices. Hippocampus 2007, 17: 709–722.CrossRefGoogle Scholar
  13. 13.
    Biella G, Uva L, de Curtis M. Propagation of neuronal activity along the neocortical–perirhinal–entorhinal pathway in the guinea pig. J Neurosci 2002, 22: 9972–9979.CrossRefGoogle Scholar
  14. 14.
    van Strien NM, Cappaert NLM, Witter MP. The anatomy of memory: an interactive overview of the parahippocampal-hippocampal network. Nat Rev Neurosci 2009, 10: 272–282.CrossRefGoogle Scholar
  15. 15.
    Kosel KC, Van Hoesen GW, Rosene DL. A direct projection from the perirhinal cortex (area 35) to the subiculum in the rat. Brain Res 1983, 269: 347–351.CrossRefGoogle Scholar

Copyright information

© Shanghai Institutes for Biological Sciences, CAS 2019

Authors and Affiliations

  1. 1.State Key Laboratory of Cognitive Neuroscience & Learning, IDG/McGovern Institute for Brain ResearchBeijing Normal UniversityBeijingChina
  2. 2.Department of Joint SurgeryThe 6th Hospital of NingboNingboChina

Personalised recommendations