Toll of Mental Disorders: TLR-Mediated Function of the Innate Immune System

  • Jian-Feng Liu
  • Ruyan Wu
  • Jun-Xu Li

Mental disorder is defined as a syndrome characterized by clinically significant disturbance in an individual’s cognition, emotion, or behavior that reflects a dysfunction in the psychological, biological, or developmental processes underlying mental functioning (DSM-V). The economic cost of mental disorders is increasing along with the increased prevalence of mental disorders worldwide. According to the 2016 National Survey on Drug Use and Health, nearly 18.5% of adults are experiencing mental disorders in the United States ( However, our poor understanding of the complicated pathology of mental disorders is an obstacle to the development of effective treatments.

Traditional opinions on the pathology of most mental disorders focus on disturbances of specific neurotransmitters [1]. For example, major depression, the most common mental disorder, is linked with abnormal regulation of...



This work was supported by the National Institutes of Health National Institute on Drug Abuse (R21DA040777). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Conflict of interest

The authors declare no conflict of interest.


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Copyright information

© Shanghai Institutes for Biological Sciences, CAS 2019

Authors and Affiliations

  1. 1.Department of Pharmacology and ToxicologyUniversity at BuffaloBuffaloUSA
  2. 2.School of MedicineYangzhou UniversityYangzhouChina

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