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Neuroscience Bulletin

, Volume 33, Issue 6, pp 737–746 | Cite as

Drosophila Studies on Autism Spectrum Disorders

  • Yao Tian
  • Zi Chao Zhang
  • Junhai HanEmail author
Review

Abstract

In the past decade, numerous genes associated with autism spectrum disorders (ASDs) have been identified. These genes encode key regulators of synaptogenesis, synaptic function, and synaptic plasticity. Drosophila is a prominent model system for ASD studies to define novel genes linked to ASDs and decipher their molecular roles in synaptogenesis, synaptic function, synaptic plasticity, and neural circuit assembly and consolidation. Here, we review Drosophila studies on ASD genes that regulate synaptogenesis, synaptic function, and synaptic plasticity through modulating chromatin remodeling, transcription, protein synthesis and degradation, cytoskeleton dynamics, and synaptic scaffolding.

Keywords

Autism spectrum disorders Drosophila Chromatin remodeling Synaptic scaffolding Synaptic transmission 

Notes

Acknowledgements

We apologize to those whose works have contributed greatly to our knowledge but were not sufficiently reviewed or were not cited owing to space limitations. We thank members of the Han laboratory for proof-reading. This review was supported by the National Natural Science Foundation of China (31471031, 31400927, and 31671045), and the Natural Science Foundation of Jiangsu Province, China (BK20140623).

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Copyright information

© Shanghai Institutes for Biological Sciences, CAS and Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  1. 1.Institute of Life Sciences, The Key Laboratory of Developmental Genes and Human DiseaseSoutheast UniversityNanjingChina

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