Neuroscience Bulletin

, Volume 33, Issue 5, pp 576–584 | Cite as

Clinical Significance of REM Sleep Behavior Disorders and Other Non-motor Symptoms of Parkinsonism

  • Hong Jin
  • Jin-Ru Zhang
  • Yun Shen
  • Chun-Feng LiuEmail author


Rapid eye movement sleep behavior disorder (RBD) is one of the most common non-motor symptoms of parkinsonism, and it may serve as a prodromal marker of neurodegenerative disease. The mechanism underlying RBD is unclear. Several prospective studies have reported that specific non-motor symptoms predict a conversion risk of developing a neurodegenerative disease, including olfactory dysfunction, abnormal color vision, autonomic dysfunction, excessive daytime sleepiness, depression, and cognitive impairment. Parkinson’s disease (PD) with RBD exhibits clinical heterogeneity with respect to motor and non-motor symptoms compared with PD without RBD. In this review, we describe the main clinical and pathogenic features of RBD, focusing on its association with other non-motor symptoms of parkinsonism.


Parkinson’s disease Rapid eye movement sleep behavior disorder Risk factors Parkinsonism 



This review was supported by the National Natural Science Foundation of China (91649114), the Jiangsu Provincial Special Program of Medical Science, China (BL2014042), a Jiangsu Provincial Medical Key Discipline Project, the Suzhou Clinical Research Center of Neurological Disease (Szzx201503), Jiangsu Province Ordinary University Professional Degree Graduate Practice Innovation, China (SJZZ16-0242), and the Priority Academic Program Development of Jiangsu Higher Education Institutions, China.


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Copyright information

© Shanghai Institutes for Biological Sciences, CAS and Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  • Hong Jin
    • 1
  • Jin-Ru Zhang
    • 1
  • Yun Shen
    • 1
  • Chun-Feng Liu
    • 1
    • 2
    Email author
  1. 1.Department of Neurology and Sleep CenterThe Second Affiliated Hospital of Soochow UniversitySuzhouChina
  2. 2.Institute of NeuroscienceSoochow UniversitySuzhouChina

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