Skip to main content
SpringerLink
Log in

Homeostasis of Synapses: Expansion During Wakefulness, Contraction During Sleep

  • Research Highlight
  • Published:
Neuroscience Bulletin Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Xie M, Li C, He C, Yang L, Tan G, Yan J, et al. Short-term sleep deprivation disrupts the molecular composition of ionotropic glutamate receptors in entorhinal cortex and impairs the rat spatial reference memory. Behav Brain Res 2016, 300: 70–76.

    Article  CAS  PubMed  Google Scholar 

  2. Xie M, Yan J, He C, Yang L, Tan G, Li C, et al. Short-term sleep deprivation impairs spatial working memory and modulates expression levels of ionotropic glutamate receptor subunits in hippocampus. Behav Brain Res 2015, 286: 64–70.

    Article  CAS  PubMed  Google Scholar 

  3. Tononi G, Cirelli C. Sleep and synaptic homeostasis: a hypothesis. Brain Res Bull 2003, 62: 143–150.

    Article  PubMed  Google Scholar 

  4. Tononi G, Cirelli C. Sleep function and synaptic homeostasis. Sleep Med Rev 2006, 10: 49–62.

    Article  PubMed  Google Scholar 

  5. Li Y, Chen F, Hu ZA. Weakening synapse to baseline during sleep. Prog Biochem Biophys 2009, 36: 269–273.

    Article  Google Scholar 

  6. Bushey D, Tononi G, Cirelli C. Sleep and synaptic homeostasis: structural evidence in Drosophila. Science 2011, 332: 1576–1581.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. de Vivo L, Bellesi M, Marshall W, Bushong EA, Ellisman MH, Tononi G, et al. Ultrastructural evidence for synaptic scaling across the wake/sleep cycle. Science 2017, 355: 507–510.

    Article  PubMed  Google Scholar 

  8. Diering GH, Nirujogi RS, Roth RH, Worley PF, Pandey A, Huganir RL. Homer1a drives homeostatic scaling-down of excitatory synapses during sleep. Science 2017, 355: 511–515.

    Article  CAS  PubMed  Google Scholar 

  9. Yang G, Lai CS, Cichon J, Ma L, Li W, Gan WB. Sleep promotes branch-specific formation of dendritic spines after learning. Science 2014, 344: 1173–1178.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Li W, Ma L, Yang G, Gan WB. REM sleep selectively prunes and maintains new synapses in development and learning. Nat Neurosci 2017, 20: 427–437.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Physiology, Collaborative Innovation Center for Brain Science, Third Military Medical University, Chongqing, 400038, China

    Chao He & Zhian Hu

Authors
  1. Chao He
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Zhian Hu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Chao He or Zhian Hu.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

He, C., Hu, Z. Homeostasis of Synapses: Expansion During Wakefulness, Contraction During Sleep. Neurosci. Bull. 33, 359–360 (2017). https://doi.org/10.1007/s12264-017-0130-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12264-017-0130-5

Keywords

Search

Navigation