Neuroscience Bulletin

, Volume 32, Issue 1, pp 108–114

The Orphan Nuclear Receptor TLX/NR2E1 in Neural Stem Cells and Diseases


DOI: 10.1007/s12264-015-0004-7

Cite this article as:
Wang, T. & Xiong, JQ. Neurosci. Bull. (2016) 32: 108. doi:10.1007/s12264-015-0004-7


The human TLX gene encodes an orphan nuclear receptor predominantly expressed in the central nervous system. Tailess and Tlx, the TLX homologues in Drosophila and mouse, play essential roles in body-pattern formation and neurogenesis during early embryogenesis and perform crucial functions in maintaining stemness and controlling the differentiation of adult neural stem cells in the central nervous system, especially the visual system. Multiple target genes and signaling pathways are regulated by TLX and its homologues in specific tissues during various developmental stages. This review aims to summarize previous studies including many recent updates from different aspects concerning TLX and its homologues in Drosophila and mouse.


TLX Neural stem cell Neurogenesis 

Copyright information

© Shanghai Institutes for Biological Sciences, CAS and Springer Science+Business Media Singapore Pte Ltd 2016

Authors and Affiliations

  1. 1.Department of Intensive Care, Southwest HospitalThird Military Medical UniversityChongqingChina

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