Neuroscience Bulletin

, Volume 31, Issue 1, pp 4–12 | Cite as

Grey matter volume abnormalities in patients with bipolar I depressive disorder and unipolar depressive disorder: a voxel-based morphometry study

  • Yi Cai
  • Jun Liu
  • Li Zhang
  • Mei Liao
  • Yan Zhang
  • Lifeng Wang
  • Hongjun Peng
  • Zhong He
  • Zexuan Li
  • Weihui Li
  • Shaojia Lu
  • Yuqiang Ding
  • Lingjiang LiEmail author
Original Article


Bipolar disorder and unipolar depressive disorder (UD) may be different in brain structure. In the present study, we performed voxel-based morphometry (VBM) to quantify the grey matter volumes in 23 patients with bipolar I depressive disorder (BP1) and 23 patients with UD, and 23 age-, gender-, and education-matched healthy controls (HCs) using magnetic resonance imaging. We found that compared with the HC and UD groups, the BP1 group showed reduced grey matter volumes in the right inferior frontal gyrus and middle cingulate gyrus, while the UD group showed reduced volume in the right inferior frontal gyrus compared to HCs. In addition, correlation analyses revealed that the grey matter volumes of these regions were negatively correlated with the Hamilton depression rating scores. Taken together, the results of our study suggest that decreased grey matter volume of the right inferior frontal gyrus is a common abnormality in BP1 and UD, and decreased grey matter volume in the right middle cingulate gyrus may be specific to BP1.


bipolar depressive disorder unipolar depressive disorder prefrontal cortex cingulate gyrus voxel-based morphometry 


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Copyright information

© Shanghai Institutes for Biological Sciences, CAS and Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Yi Cai
    • 1
    • 3
    • 4
  • Jun Liu
    • 2
  • Li Zhang
    • 1
  • Mei Liao
    • 1
  • Yan Zhang
    • 1
  • Lifeng Wang
    • 1
  • Hongjun Peng
    • 1
    • 5
  • Zhong He
    • 2
  • Zexuan Li
    • 1
  • Weihui Li
    • 1
  • Shaojia Lu
    • 1
  • Yuqiang Ding
    • 1
    • 6
  • Lingjiang Li
    • 1
    • 7
    Email author
  1. 1.Mental Health Institute of the Second Xiangya Hospital, National Technology Institute of Psychiatry Key Laboratory of Psychiatry and Mental Health of Hunan ProvinceCentral South UniversityChangshaChina
  2. 2.Department of Radiologythe Second Xiangya Hospital of Central South UniversityChangshaChina
  3. 3.Department of Mental Health and PsychiatryBrain Hospital of Hunan ProvinceChangshaChina
  4. 4.Hunan University of Chinese Medicine Clinical Medical CollegeChangshaChina
  5. 5.Guangzhou Psychiatric HospitalAffiliated Hospital of Guangzhou Medical CollegeGuangzhouChina
  6. 6.Key Laboratory of Arrhythmias, Ministry of Education, East HospitalTongji University School of MedicineShanghaiChina
  7. 7.Shenzhen Kangning Hospital of Guangdong ProvinceShenzhenChina

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