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Neuroscience Bulletin

, Volume 29, Issue 1, pp 111–120 | Cite as

Combination of Aβ clearance and neurotrophic factors as a potential treatment for Alzheimer’s disease

  • Lian-Feng Lin
  • Min-Jing Liao
  • Xiao-Yan Xue
  • Wei Zhang
  • Li Yan
  • Liang Cai
  • Xiao-Wen Zhou
  • Xing Zhou
  • Huan-Min LuoEmail author
Review

Abstract

There is no effective drug to treat Alzheimer’s disease (AD), a neurodegenerative disease affecting an estimated 30 million people around the world. Strongly supported by preclinical and clinical studies, amyloid-beta (Aβ) may be a target for developing drugs against AD. Meanwhile, the fact that localized neuronal death/loss and synaptic impairment occur in AD should also be considered. Neuronal regeneration, which does not occur normally in the mammalian central nervous system, can be promoted by neurotrophic factors (NTFs). Evidence from clinical trials has shown that both Aβ clearance and NTFs are potentially effective in treating AD, thus a new approach combining Aβ clearance and administration of NTFs may be an effective therapeutic strategy.

Keywords

Alzheimer’s disease amyloid-beta neurotrophic factors treatment 

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Copyright information

© Shanghai Institutes for Biological Sciences, CAS and Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Lian-Feng Lin
    • 1
  • Min-Jing Liao
    • 1
    • 4
  • Xiao-Yan Xue
    • 5
  • Wei Zhang
    • 1
  • Li Yan
    • 1
  • Liang Cai
    • 1
  • Xiao-Wen Zhou
    • 1
  • Xing Zhou
    • 1
  • Huan-Min Luo
    • 1
    • 2
    • 3
    Email author
  1. 1.Department of PharmacologyJinan UniversityGuangzhouChina
  2. 2.Institute of Brain Sciences, School of MedicineJinan UniversityGuangzhouChina
  3. 3.The Joint Laboratory of Brain Function and HealthJinan University and The University of Hong Kong, Jinan UniversityGuangzhouChina
  4. 4.Department of Laboratory MedicineMedical College of Hunan Normal UniversityChangshaChina
  5. 5.Ganzhou People’s HospitalGanzhouChina

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