Compromised cerebrovascular modulation in chronic anxiety: evidence from cerebral blood flow velocity measured by transcranial Doppler sonography
- 143 Downloads
Cerebral autoregulation (CA) is the mechanism by which constant cerebral blood flow is maintained despite changes in cerebral perfusion pressure. CA can be evaluated by dynamic monitoring of cerebral blood flow velocity (CBFV) with transcranial Doppler sonography (TCD). The present study aimed to explore CA in chronic anxiety.
Subjects with Hamilton anxiety scale scores ≥14 were enrolled and the dynamic changes of CBFV in response to an orthostatic challenge were investigated using TCD.
In both the anxious and the healthy subjects, the mean CBFV was significantly lower in the upright position than when supine. However, the CBFV changes from supine to upright differed between the anxious and the healthy groups. Anxious subjects showed more pronounced decreases in CBFV with abrupt standing.
Our results indicate that cerebrovascular modulation is compromised in chronic anxiety; anxious subjects have some insufficiency in maintaining cerebral perfusion after postural change. Given the fact that anxiety and impaired CA are associated with cardiovascular disease, early ascertainment of compromised cerebrovascular modulation using TCD might suggest interventional therapies in the anxious population, and improve the primary prevention of cardiovascular disease.
Keywordscardiovascular dysautonomia cerebral blood flow velocity anxiety transcranial Doppler sonography
Unable to display preview. Download preview PDF.
- Guo ZN, Xing Y, Yang L, Huang Y, Zhang L, Luan SX, et al. Elementary study about the supine-standing cerebral blood flow in patients with anxiety. J Apoplexy Nerv Dis 2011, 28: 50–52. [Article in Chinese]Google Scholar
- Rutledge T, Linke SE, Krantz DS, Johnson BD, Bittner V, Eastwood JA, et al. Comorbid depression and anxiety symptoms as predictors of cardiovascular events: results from the NHLBIsponsored Women’s Ischemia Syndrome Evaluation (WISE) study. Psychosom Med 2009, 71: 958–964.PubMedCrossRefGoogle Scholar
- Yang L, Yang Y, He SY, Xin ZE, Guo ZN. Use of transcranial Doppler sonography to evaluate patients with anxiety disorders before and after treatment. Chin J Lab Diagn 2012; 16: 1324–1325. [Article in Chinese]Google Scholar