Neuroscience Bulletin

, Volume 28, Issue 3, pp 316–320 | Cite as

Hypoxic preconditioning in an autohypoxic animal model

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Abstract

Hypoxic preconditioning refers to the exposure of organisms, systems, organs, tissues or cells to moderate hypoxia/ischemia that results in increased resistance to a subsequent episode of severe hypoxia/ischemia. In this article, we review recent research based on a mouse model of repeated exposure to autohypoxia. Pre-exposure markedly increases the tolerance to or protection against hypoxic insult, and preserves the cellular structure of the brain. Furthermore, the hippocampal activity amplitude and frequency of electroencephalogram, latency of cortical somatosensory-evoked potential and spinal somatosensory-evoked potential progressively decrease, while spatial learning and memory improve. In the brain, detrimental neurochemicals such as free radicals are down-regulated, while beneficial ones such as adenosine are upregulated. Also, antihypoxia factor(s) and gene(s) are activated. We propose that the tolerance and protective effects depend on energy conservation and plasticity triggered by exposure to hypoxia via oxygen-sensing transduction pathways and hypoxia-inducible factor-initiated cascades. A potential path for further research is the development of devices and pharmaceuticals acting on antihypoxia factor(s) and gene(s) for the prevention and treatment of hypoxia and related syndromes.

Keywords

hypoxia hypoxic preconditioning adaptive medicine 
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Copyright information

© Shanghai Institutes for Biological Sciences, CAS and Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Medical SchoolLishui UniversityLishuiChina
  2. 2.Institute for Hypoxia MedicineCapital Medical UniversityBeijingChina
  3. 3.School of Basic Medical Sciences, Department of NeurobiologyCapital Medical UniversityBeijingChina
  4. 4.Biomedicine Research Center and Basic Medical CollegeBaotou Medical CollegeBaotouChina

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