Genes & Nutrition

, Volume 5, Issue 4, pp 275–283 | Cite as

Connecting the Human Variome Project to nutrigenomics

  • Jim Kaput
  • Chris T. Evelo
  • Giuditta Perozzi
  • Ben van Ommen
  • Richard Cotton
Commentary

Abstract

Nutrigenomics is the science of analyzing and understanding gene–nutrient interactions, which because of the genetic heterogeneity, varying degrees of interaction among gene products, and the environmental diversity is a complex science. Although much knowledge of human diversity has been accumulated, estimates suggest that ~90% of genetic variation has not yet been characterized. Identification of the DNA sequence variants that contribute to nutrition-related disease risk is essential for developing a better understanding of the complex causes of disease in humans, including nutrition-related disease. The Human Variome Project (HVP; http://www.humanvariomeproject.org/) is an international effort to systematically identify genes, their mutations, and their variants associated with phenotypic variability and indications of human disease or phenotype. Since nutrigenomic research uses genetic information in the design and analysis of experiments, the HVP is an essential collaborator for ongoing studies of gene–nutrient interactions. With the advent of next generation sequencing methodologies and the understanding of the undiscovered variation in human genomes, the nutrigenomic community will be generating novel sequence data and results. The guidelines and practices of the HVP can guide and harmonize these efforts.

Keywords

Nutrigenomics Human Variome Project Harmonization 

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Jim Kaput
    • 1
  • Chris T. Evelo
    • 2
  • Giuditta Perozzi
    • 3
  • Ben van Ommen
    • 4
  • Richard Cotton
    • 5
  1. 1.Division of Personalised Nutrition and MedicineFDA/National Center for Toxicological ResearchJeffersonUSA
  2. 2.Department of Bioinformatics (BiGCaT)Maastricht UniversityMaastrichtThe Netherlands
  3. 3.INRAN—National Research Institute on Food & NutritionRomeItaly
  4. 4.TNO Quality of LifeZeistThe Netherlands
  5. 5.Genomic Disorders Research CentreMelbourneAustralia

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