Genes & Nutrition

, Volume 2, Issue 4, pp 319–322

Caffeic acid phenethyl ester inhibits invasion and expression of matrix metalloproteinase in SK-Hep1 human hepatocellular carcinoma cells by targeting nuclear factor kappa B

  • Ki Won Lee
  • Nam Joo Kang
  • Jong Hun Kim
  • Kyoung Mi Lee
  • Dong Eun Lee
  • Haeng Jeon Hur
  • Hyong Joo Lee
Research Paper

DOI: 10.1007/s12263-007-0067-9

Cite this article as:
Lee, K.W., Kang, N.J., Kim, J.H. et al. Genes Nutr (2008) 2: 319. doi:10.1007/s12263-007-0067-9

Abstract

Numerous studies have shown that the levels of matrix metalloproteinase (MMP)-2 and/or MMP-9 are associated with the invasive phenotypes of cancer cells. This study investigated the effects of caffeic acid phenethyl ester (CAPE), a chemopreventive phytochemical derived from honeybee propolis, on the invasive phenotype of SK-Hep1 human hepatocellular carcinoma cells (SK-Hep1 cells). CAPE effectively suppressed SK-Hep1 cell invasion in a dose-dependent manner. The constitutive expression of MMP-2 and MMP-9 in SK-Hep1 cells was almost completely abolished by treatment with 12.5 μM CAPE. CAPE also significantly inhibited nuclear factor kappa B (NF-κB) DNA-binding activity in SK-Hep1 cells. These results taken together suggest that CAPE exerts antimetastatic potential through inhibition of MMP-2 and MMP-9 expression, possibly by targeting NF-κB in hepatocellular carcinoma.

Keywords

Caffeic acid phenethyl ester Hepatocellular carcinoma Invasion Matrix metalloproteinases Nuclear factor kappa B 

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Ki Won Lee
    • 1
    • 2
  • Nam Joo Kang
    • 1
  • Jong Hun Kim
    • 1
    • 2
  • Kyoung Mi Lee
    • 1
  • Dong Eun Lee
    • 1
  • Haeng Jeon Hur
    • 1
  • Hyong Joo Lee
    • 1
  1. 1.Department of Agricultural Biotechnology and Center for Agricultural Biomaterials, College of Agriculture and Life SciencesSeoul National UniversitySeoulRepublic of Korea
  2. 2.Department of Bioscience and BiotechnologyKonkuk UniversitySeoulRepublic of Korea

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