Genes & Nutrition

, Volume 2, Issue 3, pp 245–248 | Cite as

Sideways Glance: Genome wide association studies for type 2 diabetes mellitus

Literature Highlights

Abbreviations

BMI

Body mass index

CDK5

Cyclin-dependent kinase 5

CDKAL1

Cyclin-dependent kinase 5-regulatory subunit associated protein 1-like 1

CDKN2A/B

Cyclin-dependent kinase-inhibitor A and B

FTO

Fat mass and obesity associated

GWAS

Genome wide association studies

HHEX

Homeobox, hematopoietically expressed

IDE

Insulin-degrading enzyme

IGF2BP2

Insulin-like growth factor 2 mRNA binding protein 2

KCNJ11

Potassium rectifying channel, sub-family J member 11

OR

Odd risk

PPARG

Peroxisome proliferator-activated receptor-gamma

SNP

Single nucleotide polymorphism

TCF7L2

Transcription factor 2, hepatic

T2DM

Type 2 diabetes mellitus

References

  1. 1.
    Amos CI (2007) Successful design and conduct of genome-wide association studies. Hum Mol Genet 16:R220–R225 PubMedCrossRefGoogle Scholar
  2. 2.
    Cauchi S, El Achhab Y, Choquet H et al (2007) TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis. J Mol Med 85:777–782PubMedCrossRefGoogle Scholar
  3. 3.
    Chimienti F, Devergnas S, Pattou F et al (2006) In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion. J Cell Sci 119:4199–4206PubMedCrossRefGoogle Scholar
  4. 4.
    Das SK, Elbein SC (2006) The genetic basis of type 2 diabetes. Cellscience 2:100–131PubMedGoogle Scholar
  5. 5.
    Frayling TM (2007) Genome-wide association studies provide new insights into type 2 diabetes aetiology. Nat Rev Genet 8:657–662PubMedCrossRefGoogle Scholar
  6. 6.
    Hattersley AT (2007) Prime suspect: the TCF7L2 gene and type 2 diabetes risk. J Clin Invest 117:2077–2079PubMedCrossRefGoogle Scholar
  7. 7.
    Kaput J, Noble J, Hatipoglu B et al (2007) Application of nutrigenomic concepts to Type 2 diabete mellitus. Nutr Metab Cardiovasc Dis 17:89–103PubMedCrossRefGoogle Scholar
  8. 8.
    Lyssenko V, Lupi R, Marchetti P et al (2007) Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest 117:2155–2163PubMedCrossRefGoogle Scholar
  9. 9.
    McCarthy MI, Zeggini E (2006) Genetics of type 2 diabetes. Curr Diab Rep 6:147–154PubMedCrossRefGoogle Scholar
  10. 10.
    Neel JV (1976) In: W Creutzfeldt J Kobberling JV Neel (eds) The genetics of diabetes mellitus. Springer, Berlin, pp 1–11Google Scholar
  11. 11.
    Owen KR, McCarthy MI (2007) Genetics of type 2 diabetes. Curr Opin Genet Dev 17:239–244PubMedCrossRefGoogle Scholar
  12. 12.
    Pavkov ME, Hanson RL, Knowler WC et al (2007) Changing patterns of type 2 diabetes incidence among Pima Indians. Diabetes Care 30:1758–1763PubMedCrossRefGoogle Scholar
  13. 13.
    Saxena R, Voight BF, Lyssenko V et al (2007) Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316:1331–1336PubMedCrossRefGoogle Scholar
  14. 14.
    Scott LJ, Mohlke KL, Bonnycastle LL et al (2007a) A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316:1341–1345PubMedCrossRefGoogle Scholar
  15. 15.
    Scott MW, Canter JA, Crawford DC et al (2007b) Letter: problems with genome-wide association studies. Science 316:1841–1842CrossRefGoogle Scholar
  16. 16.
    Shriner D, Vaughan LK, Padilla MA et al (2007) Letter: problems with genome-wide association studies. Science 316:1840–1841PubMedCrossRefGoogle Scholar
  17. 17.
    Sladek R, Rocheleau G, Rung J et al (2007) A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445:881–885PubMedCrossRefGoogle Scholar
  18. 18.
    Steinthorsdottir V, Thorleifsson G, Reynisdottir I et al (2007) A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet 39:770–775PubMedCrossRefGoogle Scholar
  19. 19.
    Weedon MN (2007) The importance of TCF7L2. Diabet Med 24:1062–1066PubMedCrossRefGoogle Scholar
  20. 20.
    Weedon MN, McCarthy MI, Hitman G et al (2006) Combining information from common type 2 diabetes risk polymorphisms improves disease prediction. PLoS Med 3:e374PubMedCrossRefGoogle Scholar
  21. 21.
    Wellcome Trust Case Control Consortium (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447:661–678CrossRefGoogle Scholar
  22. 22.
    Zeggini E (2007) A new era for type 2 diabetes genetics. Diabet Med 24:1181–1186PubMedCrossRefGoogle Scholar
  23. 23.
    Zeggini E, Weedon MN, Lindgren CM et al. (2007) Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316:1336–1341PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  1. 1.INRANRomeItaly

Personalised recommendations