Genes & Nutrition

, Volume 2, Issue 1, pp 67–70 | Cite as

Overview of genes, diet and cancer

  • J. C. MathersEmail author


Quantitative epidemiological analysis suggests that about one third of the variation in cancer risk can be attributed to variation in dietary exposure but it has proved difficult, using conventional epidemiological approaches, to identify which dietary components, in what amounts and over what time-scales are protective or potentially hazardous. Work in this area has been hampered by the lack of robust surrogate endpoints. However, the rapidly accumulating knowledge of the biological basis of cancer and the application of post-genomic technologies are helping the development of novel biomarkers of cancer risk. Genomic damage resulting in aberrant gene expression is the fundamental cause of all cancers. Such damage includes mutations, aberrant epigenetic marking, chromosomal damage and telomere shortening. Since both external agents and normal cell functions, such as mitosis, subject the genome to frequent and diverse insults, the human cell has evolved a battery of defence mechanisms which (a) attempt to minimize such damage (including inhibition of oxidative reactions by free radical scavenging and the detoxification of potential mutagens), (b) repair the damage or (c) remove severely damaged cells by shunting them into apoptosis. When such defences fail and a tumour becomes established, further genomic damage and further alterations in gene expression enable the tumour to grow, to cope with anoxia, to develop a novel blood supply (angiogenesis), to escape from the confines of its initiation site and to establish colonies elsewhere in the body (metastasis). All of these processes are potentially modifiable by food components and by nutritional status. In addition, interactions between dietary (and other environmental and lifestyle) factors and genetic make-up [seen principally in the assembly of single nucleotide polymorphisms (SNPs) which is unique to each individual] contributes to interindividual differences in cancer risk.


Cancer Gene expression Diet Biomarkers Epigenetics 



Research in my laboratory on prevention of cancer is funded by the Medical Research Council [G0100496], the Biotechnology and Biological Sciences Research Council [D20173] and the Food Standards Agency [N12009, N12015].


  1. 1.
    Doll R, Peto R (1981) The causes of cancer: quantitative estimates of avoidable risk in the United States today. J Natl Cancer Inst 66:1191–1308PubMedGoogle Scholar
  2. 2.
    American Institute for Cancer Research/World Cancer Research Fund (1997) Food, Nutrition and the Prevention of Cancer. AICR, WashingtonGoogle Scholar
  3. 3.
    Committee on Medical Aspects of Food Policy (1998) Nutritional aspects of the development of cancer. Report on Health and Social Subjects No. 49. The Stationery Office, LondonGoogle Scholar
  4. 4.
    Bingham S, Riboli E (2004) Diet and cancer—the European prospective investigation into cancer and nutrition. Nat Rev Cancer 4:206–215PubMedCrossRefGoogle Scholar
  5. 5.
    Norat S, Bingham S, Ferrari P, Slimani N, Jenab M, Mazuir M, Overvad K, Olsen A, Tjonneland A, Clavel F, Boutron-Rualt MC, Kesse E, Boeing H, Bergman MM, Nieters A, Linseinen J, Trichopoulou A, Trichopoulos D, Tountas Y, Berrino F, Palli D, Panico S, Tumino R, Veneis P, Bueno-de-Mesquita HB, Peeters PH, Engeset D, Lund E, Skeie G, Ardanaz E, Gonzalez C, Navarro C, Quiros JR, Sanchez MJ, Berglund G, Mattisson I, Hallmans G, Palmqvist R, Day NE, Khaw KT, Key TJ, San Joaquin M, Hemon B, Saracci R, Kaaks R, Riboli E (2005) Meat, fish and colorectal cancer risk: the European Prospective Investigation into cancer and nutrition. J Natl Cancer Inst 97:906–916PubMedCrossRefGoogle Scholar
  6. 6.
    Mathers C (2000) Food and cancer prevention: human intervention studies. In: Johnson IT, Fenwick GR (eds) Dietary anticarcinogens and antimutagens. Chemical and biological aspects, Royal Society of Chemistry, Cambridge, pp 395–403Google Scholar
  7. 7.
    Baron JA, Beach M, Mandel JS, van Stolk RU, Haile RW, Sandler RS, Rothstein R, Summers RW, Snover DC, Beck GJ, Bond JH, Greenberg ER (2000) Calcium supplements for the prevention of colorectal adenomas. Calcium Polyp Prevention Study Group. N Engl J Med 340:101–107CrossRefGoogle Scholar
  8. 8.
    Alberts DS, Martinez ME, Roe DJ, Guillen-Rodriquez JM, Marshall JR, van Leeuwen JB, Reid ME, Ritenbaugh C, Vargas PA, Bhattacharyya AB, Earnest DL, Sampliner RE (2000) Lack of effect of a high-fiber cereal supplement on the recurrence of colorectal adenomas. Phoenix Colon Cancer Prevention Physicians’ Network. N Engl J Med 342:1156–1162PubMedCrossRefGoogle Scholar
  9. 9.
    Mathers JC (2004) The biological revolution—towards a mechanistic understanding of the impact of diet on cancer risk. Mutat Res 55:43–49Google Scholar
  10. 10.
    Taylor RW, Turnbull DM (2005) Mitochondrial mutations in human disease. Nat Rev Genet 6:389–402PubMedCrossRefGoogle Scholar
  11. 11.
    DePinho RA (2000) The age of cancer. Nature 408:248–254PubMedCrossRefGoogle Scholar
  12. 12.
    Hoeijmakers JHJ (2001) Genome maintenance mechanisms for preventing cancer. Nature 411:66–374CrossRefGoogle Scholar
  13. 13.
    Taylor RW, Barron MJ, Borthwick GM, Gospel A, Chinnery PF, Samuels DC, Taylor GA, Plusa SM, Needham SJ, Greaves LC, Kirkwood TBL, Turnbull DM (2003) Mitochondrial DNA mutations in human colonic crypts and stem cells. J Clin Invest 112:1351–1360PubMedCrossRefGoogle Scholar
  14. 14.
    Laird PW (2003) The power and the promise of DNA methylation markers. Nat Rev Cancer 3:253–266PubMedCrossRefGoogle Scholar
  15. 15.
    Esteller M (2006) Epigenetics provides a new generation of oncogenes and tumour-suppressor genes. Br J Cancer 94:179–183PubMedCrossRefGoogle Scholar
  16. 16.
    Fang MZ, Wang Y, Ai N, Hou Z, Sun Y, Lu H, Welsh W, Yang CS (2003) Tea polyphenol (−)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines. Cancer Res 63:7563–7570PubMedGoogle Scholar
  17. 17.
    Surh YJ (2003) Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 3:768–780PubMedCrossRefGoogle Scholar
  18. 18.
    Brash DE, Havre PA (2002) New careers for antioxidants. Proc Natl Acad Sci USA 99:13969–13971PubMedCrossRefGoogle Scholar
  19. 19.
    Collins AR, Harrington V, Drew J, Melvin R (2003) Nutritional modulation of DNA repair in a human intervention study. Carcinogenesis 24:511–515PubMedCrossRefGoogle Scholar
  20. 20.
    Ponder BAJ (2001) Cancer genetics. Nature 411:336–341PubMedCrossRefGoogle Scholar
  21. 21.
    Houlston RS, Peto J (2004) The search for low-penetrance cancer susceptibility alleles. Oncogene 23:6471–6476PubMedCrossRefGoogle Scholar
  22. 22.
    Houlston RS, Tomlinson IP (2001) Polymorphisms and colorectal tumor risk. Gastroenterology 121:282–301PubMedCrossRefGoogle Scholar
  23. 23.
    Sharp L, Little J (2004) Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review. Am J Epidemiol 159:423–443PubMedCrossRefGoogle Scholar
  24. 24.
    Welfare MR, Cooper J, Bassendine MF, Daly AK (1997) Relationship between acetylator status, smoking, and diet and colorectal cancer risk in the north-east of England. Carcinogenesis 18:1351–1354PubMedCrossRefGoogle Scholar
  25. 25.
    Chen J, Stampfer MJ, Hough HL, Garcia-Closas M, Willett WC, Hennekens CH, Kelsey KT, Hunter DJ (1998) A prospective study of N-acetytransferase genotype, red meat intake, and risk of colorectal cancer. Cancer Res 58:3307–3311PubMedGoogle Scholar
  26. 26.
    Tiemersma EW, Voskuil DW, Bunschoten A, Hogendoorn EA, Witteman BJM, Nagengast FM, Glatt HR, Kok FJ, Kampman E (2004) Risk of colorectal adenomas in relation to meat consumption, meat preparation, and genetic susceptibility in a Dutch population. Cancer Causes Control 15:225–236PubMedCrossRefGoogle Scholar
  27. 27.
    Mathers JC (2003) Nutrition and cancer prevention: diet-gene interactions. Proc Nutr Soc 62:605–610PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  1. 1.Human Nutrition Research Centre, School of Clinical Medical Sciences, William Leech BuildingUniversity of NewcastleNewcastle upon TyneUK

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