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Adrenal Gland Lymphangiomas

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Abstract

Lymphangiomas of the adrenal glands (ALs) are benign vascular lesions. Approximately, 53 cases have been reported in the literature. The current study reviews and analyzes the clinical and pathologic features of all reported ALs and additionally illustrates a typical case of adrenal lymphangioma (AL). In order to perform the review analysis, a search of the international literature for ALs in adults was conducted. Thirty-eight related articles were found. Clinical and pathological information were obtained for all the reported cases and a database was created. ALs were detected more frequently in women than men. The mean age of occurrence was 39.5 years, while their mean size was 8.86 cm. Fifty-nine percent of ALs were right-sided. Size and localization were responsible for the presenting symptoms, though 30.4 % were asymptomatic. Diagnosis was made postoperatively in all cases by histological results. ALs are rare and benign lesions. They usually present as an incidental finding after abdominal imaging. The diagnosis is made after the surgical removal by histological and immunohistochemical examinations.

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Abbreviations

AL:

Adrenal lymphangioma

F:

Female

M:

Male

US:

Ultrasonography

CT:

Computed tomography

MRI:

Magnetic resonance imaging

References

  1. Ates LE, Kapran Y, Erbil Y, Barbados U, Dizdaroglou F (2005) Cystic lymphangioma of the right adrenal gland. Pathol Oncol Res 11:242–244

    Article  PubMed  Google Scholar 

  2. Ellis CL, Banerjee P, Carney E, Sharma R, Netto GJ (2011) Adrenal lymphangioma: clinicopathologic and immunohistochemical characteristics of a rare lesion. Hum Pathol 42(7):1013–1018

    Article  CAS  PubMed  Google Scholar 

  3. Lynn RB (1965) Cystic lymphangiomas of the adrenal associated with arterial hypertension. Can J Surg 8:92–95

    CAS  PubMed  Google Scholar 

  4. Gruet M, Piquard B, Ducloux M (1969) Cystic lymphangioma of the adrenal in an African woman. Bull Soc Med Afr Noire Lang Fr 14(3):549–554

    CAS  PubMed  Google Scholar 

  5. Boscaino N, D’Alessandro G, Romano C, Bruzzese E, De Falco A (1977) Study of suprarenal cysts. apropos of a case of cystic lymphagioma of the adrenal glands. Minerva Chir 32:939–946

    CAS  PubMed  Google Scholar 

  6. Lesobre B, Piéron R, Mafart Y, Coppin M, Horiot A, Helenon C, Favre M (1977) Cystic lymphangioma of the adrenal gland with arterial hypertension. Sem Hop 53:377–382

    CAS  PubMed  Google Scholar 

  7. Georgi M, Weiss H, Trede M, Saeger HD, Bleyl U, von Mittelstaedt G (1982) Radiologic differential diagnosis of adrenal gland cysts. Röfo 137:637–646

    CAS  PubMed  Google Scholar 

  8. Millon G, Toulouse J, Etievent JP, Saint-Hillier Y, Perol C, Bittard M (1982) Cystic lymphangioma of the adrenal gland causing arterial hypertension. J Urol (Paris) 88:389–392

    CAS  Google Scholar 

  9. Roumieu G, Panuel M, Clément JP (1986) Adrenal cystic lymphangioma. report of a case. J Radiol 67:693–695

    CAS  PubMed  Google Scholar 

  10. Pfister B, Henry JF, Conte-Devolx B, Lantieri O, Codaccioni JL (1987) Adrenal tumors of fortuitous discovery. 13 cases. Presse Med 16:1075–1078

    CAS  PubMed  Google Scholar 

  11. Gossot D, Decazes JM, Sarfati E, Dubost C (1987) Cystic hemolymphangioma of the adrenal gland. J Chir (Paris) 124:404–405

    CAS  Google Scholar 

  12. Sanromá OI, Garrido RC, Garmendia Larrea JC, Hernández Lecuona I, Arocena Lanz F (1988) Cystic lymphangioma of suprarenal gland. Arch Esp Urol 41:550–552

    Google Scholar 

  13. Gleeson MJ, McMullin JP (1988) Cystic lymphangiomata of the adrenal gland. Br J Urol 62:93–94

    Article  CAS  PubMed  Google Scholar 

  14. Costantino V, Petrin P, Da Lio C, Zaramella D, Pedrazzoli S (1993) Adrenal cystic masses. Our experience. Minerva Med 84:553–558

    CAS  PubMed  Google Scholar 

  15. Berthet B, Christophe M, Siméoni J, Jean F, Le Treut YP, Bricot R, Assadourian R (1993) Cystic lymphangioma of the adrenal gland: three misleading cases. Presse Med 22:64–66

    CAS  PubMed  Google Scholar 

  16. Camara A, Guichard R, Kanane O, Toumieux B (1994) Unilateral spontaneous hematoma of cystic lymphangioma of the adrenal gland in a pregnant woman. Presse Med 23:98–100

    CAS  PubMed  Google Scholar 

  17. Iderne A, Duchène H, Bruant P (1995) Cystic lymphangioma of the adrenal gland. J Chir (Paris) 132:87–89

    CAS  Google Scholar 

  18. Duca S, Lupu E, Popa EL, Acalovschi I, Ban A, Medeşan R (1995) Cystic lymphangioma of the adrenal gland. Chirurgia (Bucur) 44:43–47

    CAS  Google Scholar 

  19. Pérez Alapont FM, Martínez García R, Compañ Quilis A, Borrell Palanca A, García Garzón J, Gil Salom M, Garcia Sisamon F (1996) Cystic lymphangioma of the adrenal gland in adults. Review of the literature and report of a new case. Actas Urol Esp 20:739–742

    Google Scholar 

  20. Ness DT, Demeure MJ (1996) Large lymphangioma of the adrenal gland: case report. Endocr Pract 2:245–246

    Article  CAS  PubMed  Google Scholar 

  21. Mortelé KJ, Hoier MR, Mergo PJ, Ros PR (1999) Bilateral adrenal cystic lymphangiomas in nevoid basal cell carcinoma (Gorlin-Goltz) syndrome: US, CT, and MR findings. J Comput Assist Tomogr 23:562–564

    Article  PubMed  Google Scholar 

  22. Hoeffel CC, Kamoun J, Aubert JP, Chelle C, Hoeffel JC, Claudon M (1999) Bilateral cystic lymphangioma of the adrenal gland. South Med J 92:424–427

    Article  CAS  PubMed  Google Scholar 

  23. Longo JM, Jafri SZ, Bis KB (2000) Adrenal lymphangioma: a case report. Clin Imaging 24:104–106

    Article  CAS  PubMed  Google Scholar 

  24. Trojan J, Schwarz W, Zeuzem S, Dietrich CF (2000) Cystic adrenal lymphangioma: incidental diagnosis on abdominal sonography. AJR 174:1164–1165

    Article  CAS  PubMed  Google Scholar 

  25. Yokota M, Tanaka K, Shiotsu T, Tamura M, Nakamura S, Yamasaki Y (2000) Lymphangiomatous adrenal cyst: a case report. Nishinihon J Urol 62:318–321

    Google Scholar 

  26. Touiti D, Deligne E, Cherras A, Fehri HF, Maréchal JM, Dubernard JM (2003) Cystic lymphangioma in the adrenal gland: a case report. Ann Urol (Paris) 37:170–172

    Article  CAS  Google Scholar 

  27. Satou T, Uesugi T, Nakai Y, Hayashi Y, Imano M, Hashimoto S (2003) Case of adrenal lymphangioma with atypical lymphocytes in aspirate cytology. Diagn Cytopathol 29:87–90

    Article  PubMed  Google Scholar 

  28. Luncă S, Romedea NS, Roată C, Bouras G (2004) Cystic lymphangioma of the adrenal gland. Chirurgia (Bucur) 99:255–258

    Google Scholar 

  29. Robledo-Ogazón F, Vargas-Rivas AE, Alvarado-Aparicio A (2004) Adrenal gland lymphangiomas. A case report. Cir Cir 72:213–216

    PubMed  Google Scholar 

  30. Garcia M, Louis LB 4th, Vernon S (2004) Cystic adrenal lymphangioma. Arch Pathol Lab Med 128:713–714

    PubMed  Google Scholar 

  31. Nouira K, Bedioui H, Belhiba H, Daghfous A, Baccar S, Menif E, Ben Safta Z, Slim R (2007) Cystic lymphangioma of the adrenal gland, from radiologic diagnosis to laparoscopic treatment. A case report. Tunis Med 85:160–162

    PubMed  Google Scholar 

  32. Bettaïeb I, Mekni A, Bédioui H, Nouira K, Chelly I, Haouet S, Bellil S, Bellil K, Kchir N, Zitouna M (2007) Huge cystic lymphangioma of the adrenal gland. A case report and review of the literature. Pathologica 99:19–21

    PubMed  Google Scholar 

  33. Pereira Gallardo S, Gómez Torres FJ, Torres Olivera FJ (2007) Cystic lymphangioma of the adrenal glands. Case report. Arch Esp Urol 60:187–189

    Article  CAS  PubMed  Google Scholar 

  34. Chien HP, Chang YS, Hsu PS, Lin JD, Wu YC, Chang HL, Chuang CK, Tsuei KH, Hsueh C (2008) Adrenal cystic lesions: a clinocopathological analysis of 25 cases with proposed histogenesis and review of the literature. Endocr Pathol 19:274–281

    Article  PubMed  Google Scholar 

  35. Ait Ali A, Sall I, Kaoui H, Bouchentouf M, Hajjouji A, Jeddou CO, Zentar A, Sair K (2009) Abdominal cystic lymphangioma in the adult. An exceptionally polymorphous tumor. J Afr Hepato Gastrenterol 3:7–12

    Article  Google Scholar 

  36. Cutaja V, Lo Re G, Midiri M (2009) Cystic lymphangioma of adrenal gland. Case report and review of the literature. Acta Medica Mediterranea 25:133–137

    Google Scholar 

  37. Bisceglia M, Carosi I, Scillitani A, Pasquinelli G (2009) Cystic lymphangioma-like adenomatoid tumor of the adrenal gland: case presentation and review of the literature. Adv Anat Pathol 16:424–432

    Article  PubMed  Google Scholar 

  38. Sallami S, Chelly I, Nidhameddine K (2013) Adrenal cystic lymphangioma. Tunis Med 91(1):77–78

    PubMed  Google Scholar 

  39. Liu B, Li Y, Wang S (2013) Adrenal lymphangioma removed by a retroperitoneoscopic procedure. Oncol lett 5(2):539–540

    PubMed  PubMed Central  Google Scholar 

  40. Berthet B, Assadourian R (1989) A complication of adrenal cystic lymphangioma: hemorrhage. Presse Med 18:939

    CAS  PubMed  Google Scholar 

  41. Constantino V, Pasqualli C, Liessi G (1992) Linfangioma cistico surrenalico. Presentazione di un caso. Minerva Chir 47:1841–1845

    Google Scholar 

  42. Solomou EG, Patriarheas GV, Mpadra FA, Karamouzis MV, Dimopoulos I (2003) Asymptomatic adult cystic lymphangioma of the spleen: case report and review of the literature. Magn Reson Imag (MRI) 21:81–84

    Article  CAS  Google Scholar 

  43. Poncelet V (1998) Retroperitoneal cystic lymphangioma. J Belge Radiol 81:245

    CAS  PubMed  Google Scholar 

  44. Kim JK, Yoo KS, Moon JH, Park KH, Chung YW, Kim KO, Park KH, Hahn T, Park SH, Kim JH, Jeon JY, Kim MJ, Min KS, Park CK (2007) Gallbladder lymphangioma: a case report and review of the literature. World J Gastroenterol 13:320–323

    Article  PubMed  PubMed Central  Google Scholar 

  45. Sanal TH, Kocaoglu M, Yildirim D, Bulakbasi N, Guvenc I, Tayfun C, Ucoz T (2006) Imaging features of benign adrenal cysts. Eur J Radiol 60:465–469

    Article  PubMed  Google Scholar 

  46. Rozenblit A, Morehouse HT, Amis ES (1996) Cystic adrenal lesions: CT features. Radiology 201:541–549

    Article  CAS  PubMed  Google Scholar 

  47. Elsayes KM, Mukundan G, Narra VR, Lewis JS Jr, Shirkhoda A, Farooki A, Brown JJ (2004) Adrenal masses: MR imaging features with pathologic correlation. Radiographics 24:S73–S86

    Article  PubMed  Google Scholar 

  48. Lubikowski J, Umiński M, Andrysiak-Mamos E, Pynka S, Fuchs H, Wójcicki M, Szajko M, Moleda P, Post M, Zochowska E, Kiedrowicz B, Safranow K, Syrenicz A (2010) From open to laparoscopic adrenalectomy: thirty years’ experience of one medical centre. Endokrynol Pol 61:94–101

    PubMed  Google Scholar 

  49. Phitayakorn R, McHenry CR (2008) Laparoscopic and selective open resection for adrenal and extraadrenal neuroendocrine tumors. Am Surg 74:37–42

    PubMed  Google Scholar 

  50. Zografos NG, Farfaras A, Vasiliadis G, Pappa T, Aggeli C, Vasilatou E, Kaltsas G, Piaditis G (2010) Laparoscopic resection of large adrenal tumors. JSLS 14:364–368

    Article  PubMed  PubMed Central  Google Scholar 

  51. Kalof AN, Cooper K (2009) D2-40 immunohistochemistry so far! Adv Anat Pathol 16:62–64

    Article  CAS  PubMed  Google Scholar 

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Conflict of Interest

The authors declare that they have no conflicts of interest to report.

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Authors and Affiliations

  1. 3rd Department of Surgery, Aristotle University of Thessaloniki, AHEPA University Hospital, 56 Papanastasiou Str, Thessaloniki, 54642, Greece

    Nick Michalopoulos, Styliani Laskou, Leonidas Pavlidis & Ioannis Kanellos

  2. Pathology Department, Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece

    Georgia Karayannopoulou

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  1. Nick Michalopoulos
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  2. Styliani Laskou
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Correspondence to Nick Michalopoulos.

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Michalopoulos, N., Laskou, S., Karayannopoulou, G. et al. Adrenal Gland Lymphangiomas. Indian J Surg 77 (Suppl 3), 1334–1342 (2015). https://doi.org/10.1007/s12262-015-1206-y

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  • DOI: https://doi.org/10.1007/s12262-015-1206-y

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