Kinetics and Mechanism of Ultrasound-assisted Extraction of Paclitaxel from Taxus chinensis
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Batch experimental studies were carried out for the ultrasound-assisted extraction of paclitaxel from Taxus chinensis while varying parameters such as ultrasound power, extraction temperature and contact time. The extraction of the majority of the paclitaxel (~99%) was achieved from the biomass by a single extraction at 380W of ultrasound power for a period of 10 min. The kinetics data obtained for the paclitaxel extractions, and the dominant role played by intraparticle diffusion, were found to be in concordance with the pseudo-second-order model, and the intraparticle diffusion model respectively. The effective diffusion coefficient of paclitaxel (4.1882 × 10-13 ~ 5.7093 × 10-13 m2/s) and the mass transfer coefficient (4.705 × 10-8 ~ 14.1160 × 10-8 m/s) increased when the extraction temperature and ultrasound power were raised.
Keywordspaclitaxel ultrasound-assisted extraction kinetics effective diffusion coefficient mass transfer coefficient
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- 1.Kim, J. H. (2006) Paclitaxel: recovery and purification in commercialization step. Korean J. Biotechnol. Bioeng. 21: 1–10.Google Scholar
- 9.Kim, J. H. (2000) Optimization of extraction process for mass production of paclitaxel from plant cell cultures. Korean J. Biotechnol. Bioeng. 15: 346–351.Google Scholar
- 18.Langergren, S. and B. K. Svenska (1898) Zur theoie der sogenannten adsorption geloester stoffe. Veter. Hand. 24: 1–39.Google Scholar
- 21.Weber, W. J. and J. C. Morris (1963) Kinetics of adsorption on carbon from solution. J. Sanit. Eng. Div. Am. Soc. Civ. Eng. 89: 31–59.Google Scholar
- 26.John, F. (2011) Ultrasonics - number and size of cavitation bubbles, Cleaning Technologies Group, Available from: http://techblog.ctgclean.com/2011/12/ultrsonics-number-and-size-ofcavitation-bubbles.Google Scholar