Biotechnology and Bioprocess Engineering

, Volume 17, Issue 1, pp 1–7

Synthetic regulatory tools for microbial engineering

Review Paper

DOI: 10.1007/s12257-011-0563-z

Cite this article as:
Seo, S.W., Kim, S.C. & Jung, G.Y. Biotechnol Bioproc E (2012) 17: 1. doi:10.1007/s12257-011-0563-z


Microbial engineering requires accurate information about cellular metabolic networks and a set of molecular tools that can be predictably applied to the efficient redesign of such networks. Recent advances in the field of metabolic engineering and synthetic biology, particularly the development of molecular tools for synthetic regulation in the static and dynamic control of gene expression, have increased our ability to efficiently balance the expression of genes in various biological systems. It would accelerate the creation of synthetic pathways and genetic programs capable of adapting to environmental changes in real time to perform the programmed cellular behavior. In this paper, we review current developments in the field of synthetic regulatory tools for static and dynamic control of microbial gene expression.


metabolic engineering synthetic biology expression control synthetic regulatory tools 

Copyright information

© The Korean Society for Biotechnology and Bioengineering and Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Sang Woo Seo
    • 1
  • Seong Cheol Kim
    • 2
  • Gyoo Yeol Jung
    • 1
    • 2
  1. 1.Department of Chemical EngineeringPohang University of Science and TechnologyPohangKorea
  2. 2.School of Interdisciplinary Bioscience and BioengineeringPohang University of Science and TechnologyPohangKorea

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