The top ten things that must be known about end of life therapy in patients with advanced cancer

  • Gudrun KreyeEmail author
  • Bettina Heidecker
  • Eva K. Masel
short review


End of life is an issue that affects every human being sooner or later. Several aspects at the end of life should not be neglected to achieve good symptom control. Basic knowledge and skills on symptom control and palliative care are important to support patients in this threatening phase of their life. Palliative care should not be provided only at the end of life. The concept of early integration of palliative care is increasingly coming into focus. Nevertheless, at the end of life there are some important facts and issues that should be taken into account. This short article provides a list of ten important facts at the end of life that are important for the authors. Prognostication, early integration, benzodiazepines, death rattle, palliative sedation, standard therapy for refractory dyspnea, opioids in renal failure, psylocibin, denial and reduction of drugs at the end of life will be discussed in detail.


Early integration Relevant symptoms at the end of life Psychedelic prodrug Medication at the end of life 


Conflict of interest

G. Kreye, B. Heidecker, and E.K. Masel declare that they have no competing interests.


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2020

Authors and Affiliations

  1. 1.Palliative Care Unit, Department of Internal Medicine II, University Hospital KremsKarl Landsteiner University of Health SciencesKrems an der DonauAustria
  2. 2.Campus Benjamin FranklinCharité Universitätsmedizin BerlinBerlinGermany
  3. 3.Clinical Division of Palliative Care, Department of Internal Medicine IMedical University ViennaViennaAustria

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