memo - Magazine of European Medical Oncology

, Volume 11, Issue 4, pp 317–321 | Cite as

Cure in metastatic disease: how to manage and who is the right patient in colorectal cancer?

  • Thomas GruenbergerEmail author
  • Phillip Jonas
  • Rebecca Lutz
  • Birgit Gruenberger
short review


Metastatic colorectal cancer was long considered for palliative therapy, until significant improvement in surgical techniques and more effective chemotherapeutic regimens changed the way metastatic colon cancer patients are being treated today. Prospective trials were designed to answer the question which patient with metastatic disease could potentially be cured by a multidisciplinary approach with medical oncologists, surgeons and radiation oncology using an induction chemotherapy in combination with a targeted agent and being monitored for resectability in multidisciplinary tumor boards. Patients with oligometastatic disease should be treated with the goal of curative resection. This review will highlight studies conducted over the past 15 years addressing this issue. An algorithm is proposed illustrating how every newly diagnosed mCRC (metastatic colorectal cancer) patient could be discussed in the tumor board to decide the best treatment sequence with the best chance of cure.


Liver metastases Colorectal cancer Chemotherapy Liver resection Multidisciplinarity 


Conflict of interest

T. Gruenberger, P. Jonas, R. Lutz, and B. Gruenberger declare that they have no competing interests.


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Surgery, HPB-Center, Vienna ClinicsKaiser-Franz-Josef HospitalViennaAustria
  2. 2.Department of Internal Medicine, Haematology and Medical OncologyWr Neustadt HospitalWr NeustadtAustria

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