memo - Magazine of European Medical Oncology

, Volume 7, Issue 3, pp 126–129

Highlights of the American Society of Hematology Meeting 2013: hemostaseology

short review
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Abstract

Venous thromboembolism is associated with substantial morbidity and mortality. Furthermore, the subsequently indicated anticoagulation treatment puts the patient at risk of possible bleeding complications. Therefore, improving treatment strategies as well as diagnostic approaches can optimize patient care. During the 55th Annual Meeting 2013 of the American Society of Hematology the Choosing Wisely® campaign was presented. An expert committee recommends against the test for thrombophilia after venous thromboembolism occurring in the setting of major transient risk factors to avoid over treatment in these patients. Other presentations focused on the use of the direct oral anticoagulants in patients with cancer-associated thromboembolism. However, specific studies comparing direct oral anticoagulants with the state-of the art treatment with low molecular heparins in cancer-associated thromboembolism are still missing. Finally, age-adjusted cut-off levels can increase the specificity of D-Dimer in older patients. Consequently, using clinical probability assessment in the combination with age-adjusted D-dimer cut-off levels may be associated with a larger number of patients in whom pulmonary embolism can be ruled out.

Keywords

Thrombophilia screening Venous thromboembolism Cancer Anticoagulation Age-adjusted D-dimer 

Abbreviations

ASH

American Society of Hematology

DOAC

Direct oral anticoagulant

LMWH

Low-molecular-weight heparin

UFH

Unfractionated heparin

VKA

Vitamin K antagonist

VTE

Venous thromboembolism

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Copyright information

© Springer-Verlag Wien 2014

Authors and Affiliations

  1. 1.Internal Medicine V—Hematology and OncologyMedical University of InnsbruckInnsbruckAustria

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