Clinical Effect of CD25 on the Prognosis of Diffuse Large B Cell Lymphoma with Secondary Central Nervous System Relapse

  • Satoko OkaEmail author
  • Kazuo Ono
  • Masaharu Nohgawa
Original Article


In the present study, we investigated the effects of immunophenotyping on prognosis of diffuse large B cell lymphoma (DLBCL) with central nervous system (CNS) relapse treated with rituximab-CHOP (R-CHOP). CNS relapse occurred in 9.5% of DLBCL patients. At the diagnosis of DLBCL, CD25 was detected in 14.3% of cases. CD25 positivity correlated with an advanced stage, higher R-IPI, higher CNS-IPI, the presence of B symptoms, the presence of extranodal involvement >1, and bone involvement. Moreover CNS relapse was more frequently observed in patients with CD25+ than in those with CD25-. The univariate analysis showed that an advanced stage, high-risk R-IPI, high-risk CNS-IPI, bone involvement, and CD25+ were associated with shorter overall survival (OS). The multivariate analysis confirmed that CD25+ and high-risk CNS-IPI were independent adverse prognostic factors for shorter OS. A Kaplan-Meier analysis revealed the potential of CD25+ as a prognostic factor in patients with CNS relapse and that it correlated with shorter survival. The present results showed that the expression of CD25 in DLBCL patients with CNS relapse was associated with the patient prognosis independent other prognostic factors. The establishment of a treatment strategy for CNS relapse patients with CD25+ DLBCL cells is needed to improve poor outcomes.


Diffuse large B cell lymphoma Central nervous system relapse CD25 Rituximab 


Compliance with Ethical Standards

Conflict of Interest

Satoko Oka declares that she has no conflicts of interest in the present study.

Kazuo Ono declares that he has no conflicts of interest in the present study.

Masaharu Nohgawa declares that he has no conflicts of interest in the present study.

Human Studies

This article does not contain any studies with human participants performed by any of the authors.

Informed Consent

These patients provided their written informed consent to receive each regimens, and treatments were administered according to the principles of the Declaration of Helsinki and this study was approved by the institutional ethics committee.


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Copyright information

© Arányi Lajos Foundation 2019

Authors and Affiliations

  1. 1.Division of Hematology, Japanese Red Cross Society Wakayama Medical CenterWakayamaJapan
  2. 2.Division of Pathology, Japanese Red Cross Society Wakayama Medical CenterWakayamaJapan

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