Intravascular Occlusion by Leukemic Blast Cells Causing Multiplex Hand Necrosis in a Patient with Acute Myeloid Leukemia
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In April 2017, a 76 years old female patient with a history of hypertension, hypothyreosis and left renal artery stenosis was diagnosed with acute myeloid leukemia (AML; FAB M4). She presented with poor prognostic markers including complex karyotype with wild-type FLT-3 and NPM-1 mutations. After induction chemotherapy (3 + 7 regimen, consisting 60 mg/m2 of daunorubicin and 100 mg/m2 of cytosine arabinoside) she experienced treatment failure with progressive disease and newly detected peripheral blast cells. After receiving dismal results she withdrew consent for further treatment.
Compliance with Ethical Standards
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.
Conflict of Interest
The authors declare that they have no conflict of interest.
Informed consent was obtained from all individual participants included in the study.
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