Pathology & Oncology Research

, Volume 25, Issue 2, pp 691–696 | Cite as

Combined Treatment with Autologous CIK Cells, Radiotherapy and Chemotherapy in Advanced Cervical Cancer

  • Ning Li
  • Yong-Wei Tian
  • Yue Xu
  • Dan-Dan Meng
  • Ling Gao
  • Wen-jie Shen
  • Zong-lan Liu
  • Zhi-Qiao XuEmail author
Original Article


To investigate the clinical efficacy of autologous cytokine induced killer (CIK) cells transfusion combined with radiochemotherapy in the treatment of advanced cervical cancer. A total of 89 hospitalized patients with advanced cervical cancer were admitted and divided into the treatment group (44 cases, autologous CIK cells transfusion combined with radiochemotherapy) and the control group (45 cases, radiochemotherapy) by a randomized non-blind method. Comparisons of therapeutic efficacies, immune functions, life qualities and survival rates were analyzed between the two groups. The short-term therapeutic efficacy of the treatment group was significantly higher than that of the control group. There was no significant difference in 1, 2 and 3 year survival rates between the two groups. Compared with pre-treatment, levels of CD3+, CD4+/CD8+ in peripheral blood were increased in the CIK group, which were reduced in the control group. In the CIK group,only the feeling was depressed on the 25th day post-treatment (T25) compared with the day before treatment (B1). However in the control group, the function of body, role, social and holistic health was obvious disordered on day T25 compared with day B1. On day T25, there were significant differences in function of body, social and holistic health between two groups. Autologous CIK cells transfusion combined with radiochemotherapy shows better short-term efficacy than radiochemotherapy alone in the treatment of advanced cervical cancer, which obviously improves immune function and life quality of patients with low side effects.


Autologous CIK cell Advanced cervical cancer Radiochemotherapy 



This study was supported by the Science and Technology Research Projects of Kaifeng City.

Compliance with Ethical Standards

Conflict of Interest

The authors report no potential conflict of interest.


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Copyright information

© Arányi Lajos Foundation 2018

Authors and Affiliations

  • Ning Li
    • 1
  • Yong-Wei Tian
    • 1
  • Yue Xu
    • 1
  • Dan-Dan Meng
    • 1
  • Ling Gao
    • 1
  • Wen-jie Shen
    • 2
  • Zong-lan Liu
    • 2
  • Zhi-Qiao Xu
    • 1
    Email author
  1. 1.The Center of Tumor Diagnosis and TreatmentKaifeng Central HospitalKaifengChina
  2. 2.The Department of StatisticsKaifeng Central HospitalKaifengChina

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