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Prognostic and Clinic-Pathological Significances of SCF and COX-2 Expression in Inflammatory and Malignant Prostatic Lesions

  • Mohamed Ali Alabiad
  • Ola A. HarbEmail author
  • Heba F. Taha
  • Basant Sh El Shafaay
  • Loay M. Gertallah
  • Nashaat Salama
Original Article
  • 119 Downloads

Abstract

The initiation of prostatic malignancy has been linked to chronic inflammation. Stem cell factor (SCF) is an inflammatory cytokine that is specific to the c-KIT receptor which is type III receptor tyrosine kinase (RTK). Cyclooxygenases (COXs) are the main enzymes which are responsible for prostaglandins production from arachidonic acid. COX2 is an enzyme which is produced under different pathological conditions. The aim of our study; is to investigate the clinicopathological and the prognostic significance of SCF and COX-2 expression in prostatic adenocarcinoma (PC), chronic prostatitis and nodular prostatic hyperplasia (NPH) in a trial to clarify the role of inflammation as a risk factor for prostatic carcinogenesis and cancer progression. SCF and COX-2 tissue protein expression were evaluated in 50 cases of PC, 20 cases of chronic prostatitis and 10 cases of NPH using immunohistochemistry, patients were followed up for 5 years. The relationship between their levels of expressions, clinicopathological, and prognostic criteria were studied. SCF expression in PC was positively correlated with advanced patient age (p = <0.001), high level of PSA (p = 0.010), higher Gleason score (p = 0.011). COX-2 expression in PC was positively correlated with advanced patient age (p = <0.001), high level of PSA (p = 0.016), advanced D’Amico risk group (p = 0.038). High levels of expression of both SCF& COX-2 are associated with higher incidence of tumor relapse, worse disease overall survival and free survival (p < 0.001). SCF and COX-2 are associated with PC progression and associated with poor prognosis in PC patients.

Keywords

SCF COX-2 Prostatic adenocarcinoma Immunohistochemistry Prognosis 

Notes

Compliance with Ethical Standards

Conflict of Interest

Authors had declared no conflict of interest.

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Copyright information

© Arányi Lajos Foundation 2019

Authors and Affiliations

  1. 1.Pathology Department, Faculty of MedicineZagazig UniversityZagazigEgypt
  2. 2.Medical Oncology Department, Faculty of MedicineZagazig UniversityZagazigEgypt
  3. 3.Clinical Oncology and Nuclear Medicine Department, Faculty of MedicineZagazig UniversityZagazigEgypt
  4. 4.General Surgery Department, Faculty of MedicineZagazig UniversityZagazigEgypt
  5. 5.Urology Department, Faculty of MedicineZagazig UniversityZagazigEgypt

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