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Pathology & Oncology Research

, Volume 25, Issue 3, pp 1135–1142 | Cite as

Assessment of Gastritis and Gastric Cancer Risk in the Chilean Population Using the OLGA System

  • Enrique BellolioEmail author
  • Ismael RiquelmeEmail author
  • Angela L. Riffo-Campos
  • Carlos Rueda
  • Catterina Ferreccio
  • Miguel Villaseca
  • Priscilla Brebi
  • Sergio Muñoz
  • Juan Carlos Araya
Original Article

Abstract

Gastric cancer (GC) is the first cancer-related cause of death in Chile; however, no plan for GC early detection has been implemented in this country. The OLGA system characterizes gastritis from stages 0 to IV according to the risk of developing GC based on H. pylori infection, atrophy, metaplasia and GC. In this study, the performance of the OLGA system was evaluated in 485 Chilean patients receiving routine endoscopy to improve the detection of early GC or preneoplastic lesions. The results showed that OLGA scores, atrophy, metaplasia and GC increased significantly with age (p < 0.001). Conversely, H. pylori infection was higher in younger groups (p < 0.05). All gastric lesions were more frequent in men than women. The majority of patients with atrophy also had metaplasia (99%, p < 0.0001). Patients with H. pylori infection had more gastric atrophy and metaplasia than those without infection (p < 0.05). Of the 485 patients, 21 (4.3%) had GC, being 2.3 times more frequent among men than women and about 2/3 (14) were in OLGA stage ≥2. In addition, 19 (90%) GC patients had atrophy and 18 (85%) had metaplasia (p < 0.001). In conclusion, the OLGA system facilitated the evaluation of GC precursor lesions particularly in patients with an OLGA score > 2 between 45 and 56 years old, because this group showed atrophy and intestinal metaplasia more frequently. Therefore, biennial endoscopic surveillance of patients with an OLGA >2 can be an important health policy in Chile for diagnosing GC in its early stages and reducing mortality over the next two decades.

Keywords

The OLGA system Helicobacter pylori infection Gastric atrophy Metaplasia Gastric cancer Chilean population 

Notes

Acknowledgements

This work was supported by the DIUFRO Grant (N° DI17-0132 to MV) and The National Fund for Scientific and Technological Development (FONDECYT) Grant (N° 3170826 to IR and N° 11150802 to PB).

Compliance with Ethical Standards

Informed consent was obtained from all individual participants included in the study according to ethical requirements of WMA Declaration of Helsinki - Principles for medical research involving human subjects. We declare that this manuscript is original, has not been published before and is not currently being considered for publication elsewhere. The funders (see Acknowledgements) had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Conflicts of Interest

The authors have no conflicts of interest to declare.

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Copyright information

© Arányi Lajos Foundation 2018

Authors and Affiliations

  1. 1.Department of Pathological Anatomy, School of MedicineUniversidad de La FronteraTemucoChile
  2. 2.Instituto de Patología Celular y MolecularTemucoChile
  3. 3.Instituto de Ciencias Biomédicas, Facultad de Ciencias de la SaludUniversidad Autónoma de ChileTemucoChile
  4. 4.Centro de Excelencia de Modelación y Computación CientíficaUniversidad de La FronteraTemucoChile
  5. 5.GastroenterologistSantiagoChile
  6. 6.School of Medicine, Pontificia Universidad Católica de ChileSantiagoChile
  7. 7.Advanced Center for Chronic Diseases (ACCDiS), FONDAPSantiagoChile
  8. 8.Laboratory of Molecular Pathology, Department of Pathological Anatomy, School of Medicine, Center of Excellence in Translational Medicine - Scientific and Technological Bioresource Nucleus (CEMT-BIOREN)Universidad de La FronteraTemucoChile
  9. 9.Department of Public Health, School of MedicineUniversidad de La FronteraTemucoChile

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