WWP2 Is One Promising Novel Oncogene

  • Rui Zhang
  • Jianwu Zhang
  • Wei Luo
  • Zhuang LuoEmail author
  • Shaoqing ShiEmail author


WWP2 is an E3 ubiquitin ligase and plays an important role in regulation of many cellular biological activities through ubiquitination and degradation of its substrates. Recently accumulating evidences indicate that WWP2 plays a crucial part in the pathogenesis in different types of tumors. In this report, the role of this gene especially in tumorigenesis was reviewed. WWP2 is dysregulated in various of tumors, and it promotes carcinogenesis mainly through PTEN/Akt signaling pathway. WWP2 also participates in anti-cancer agents’ sensitivity, indicating WWP2 may be a novel target for cancer treatment. WWP2 is one promising novel oncogene.


WWP2 Cancer Akt Pathogenesis 



This study was supported in part by National Natural Science Foundation of China (No. 81860412) to S. Shi,  Yunnan Natural Science Foundation of China (2017FE468(-151) to S. Shi, 2017FE468(-200) to Z. Luo) and 100 young and middle-aged academic and technical backbone of Kunming Medical University (60117190451 to S. Shi, 60117190423 to Z. Luo).

Compliance with Ethical Standards

Conflicts of Interest

There is no potential conflict of interest or financial dependence regarding this publication.


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Copyright information

© Arányi Lajos Foundation 2018

Authors and Affiliations

  1. 1.Department of Thoracic SurgeryThe Seventh People’s Hospital of ChengduChengduPeople’s Republic of China
  2. 2.School of Pharmacy, North Sichuan Medical CollegeNanchongPeople’s Republic of China
  3. 3.Department of Respiratory MedicineThe People’s Hospital of LeshanLeshanPeople’s Republic of China
  4. 4.Department of Pumnary and Critical Care MedicineThe First Affiliated Hospital of Kunming Medical UniversityKunmingPeople’s Republic of China

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