Pathology & Oncology Research

, Volume 25, Issue 2, pp 521–525 | Cite as

Importance of Immunohistochemical Detection of Somatostatin Receptors

  • Attila ZalatnaiEmail author
  • Eszter Galambos
  • Eszter Perjési
Original Article


The long-acting somatostatin analogs represent important weapons in treatment protocols of patients with neuroendocrine tumors. Because these peptides preferentially bind to the specific somatostatin receptors, the targeted therapy requires detection of them. As one of the national consulting centers, here we present the results of the immunohistochemically positive neuroendocrine neoplasms diagnosed between 2010 and 2014. Twenty-four paraffin-embedded cases (14 females 10 men, 21–79 years) from different localizations were found to express somatostatin-receptor type 2 (SSTR2). None of the patients has received previous hormonal therapy. The immune reactions have shown membranous, cytoplasmic or mixed patterns. There was no correlation between the expression and the chromogranin A levels, the grades or the hormonal activity/inactivity of the given neoplasms. Our results show that the immunohistochemical detection of SSTR2 is a quick, reliable and effective tool that provides useful information to the oncologists for the therapeutic decision. Because the incidence of the neuroendocrine tumors is still low, centralized pathological units are needed to perform such technique.


Neuroendocrine tumors Immunohistochemistry Somatostatin receptors 



The excellent technical assistance of Zsuzsa Kaminszky is highly appreciated.

Compliance with ethical standards


The authors declare no conflict of interest.


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Copyright information

© Arányi Lajos Foundation 2018

Authors and Affiliations

  • Attila Zalatnai
    • 1
    Email author
  • Eszter Galambos
    • 1
  • Eszter Perjési
    • 1
  1. 1.First Department of Pathology and Experimental Cancer ResearchSemmelweis University, Faculty of MedicineBudapestHungary

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