Transforming Growth Factor Beta 2 Inhibits Growth and Proliferation Potential of Smad4 and p53 Mutated Human Colon Adenocarcinoma Cells
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Colon cancer is the most frequently diagnosed cancer and the second leading contributors of cancer related deaths in the United States . The American cancer society estimated that colon cancer causes about 49,190 deaths in 2016 . Although current therapeutics have proved to be clinically favourable for patients who were diagnosed at early stages, development of multi-drug resistance and various side effects remains the potential obstacle for advanced stages of colon cancer . Recent data suggests that the 5 year survival rate for advanced stage colon cancer is about 5% with increased mortality rate of more than 663,000 deaths annually worldwide [2, 3]. Molecular evidence confirmed that transforming growth factor beta (TGF-β) plays a crucial role in the metastatic progression of colon cancer and multi-drug resistance .
TGF-β regulates the expression of a plethora of genes involved in fundamental cellular processes such as cell proliferation, differentiation,...
The authors would like to acknowledge the Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur- 603203, Tamilnadu, India for the financial support.
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Conflict of interest
The authors declare that they have no conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
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