Polymorphisms in Genes Related to Cervical Cancer in A Brazilian Population: A Case-Control Study
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To the editor:
Cervical cancer (CC) is the fourth most common cancer in women, with approximately 528,000 new cases in the world each year, 80% of them in developing countries . It is well recognized that persistent infection of human papillomavirus (HPV) is the main cause of precursor lesions that progress to CC, but only a small proportion of these HPV infected women develop the disease. In this sense, polymorphisms in human genes have also been associated with CC . Genome-wide studies investigated the association of human single nucleotide polymorphisms (SNPs) with HPV persistent infection, progression to cervical intraepithelial neoplasia (CIN) and CC in Latin American women [3, 4]. More than seven thousand SNPs were investigated in genes related to immune response, DNA repair, viral replication and entry into the host cell. Association to persistent HPV progression to CIN and CC was observed with SNPs in genes of DNA repair (EXO1, CYBA, FANCA, XRCC1, GTF2H4, DUT, FLJ35220,...
The authors are grateful to the laboratory technical support of the Molecular Diagnostic Laboratory (ULBRA) group, especially Fernanda Kieling Moreira Lehmann and the Center for High Complexity in Oncology (Centro de Assistência de Alta Complexidade em Oncologia - CACON) of Ijuí for providing the samples for the present study. The authors would also like to thank the students of the Biomedicine school (UNICRUZ), Bruna Klahr Manggini, Flávio Henrique Bottura and Karolaine Funck, for the sample collections used in this study.
Financial resources to perform the laboratory analyses were obtained in the project "Study of human and viral genetic factors associated with the persistence of genital papillomavirus and progression to cervical cancer" submitted and approved in the FAPERGS /MS/CNPq/SES/RS Notice n. 002/2013 - Research Program for SUS: Shared health management PPSUS - 2013/2015. In addition, this work was also supported by the Universidade Luterana do Brasil (ULBRA) and Simbios Biotecnologia. Grivicich and Lunge were supported by the National Council of Technological and Scientific Development – CNPq (process number, 313304/2014–9). Boeira, Wolf and Coser by the Coordination of Improvement of Higher Educational Personnel – CAPES (181–18/12/2012).
Boeira, Coser, Simon, and Lunge designed the study. Boeira and Wolf managed lab work and the data analyses. Boeira, Coser, Wolf, Simon, Lunge contributed to literature review and discussion.
Compliance with Ethical Standards
Conflict of Interest
The authors declare that there is no conflict of interest.
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