Genetic Analysis of Brazilian Patients with Gallbladder Cancer
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To the Editor,
Gallbladder cancer (GBC) is a rare neoplasm with poor prognosis and overall survival . Its underlying molecular pathogenesis remains largely elusive and the accumulation of multiple somatic genetic alterations as well as chronic inflammation associated with gallstone formation promotes epithelial dysplasia and progression to adenocarcinoma postulated [2, 3, 4].
It has been shown that some indigenous people and ethnic groups have higher incidence and mortality rates, with differences within the same country and some populations identified as high-risk groups for GBC development. The highest incidence rates are found in populations living west of the Andes, northern India and populations of American and Mexican Indians .
The potential association in genetically heterogeneous Brazilian GBC patients has not been previously reported. Based in a comprehensive study  and COSMIC database (http://cancer.sanger.ac.uk/cosmic) we investigated the contribution of TP53, KRAS,...
This work was partially funded by grants from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq # 405053/2013-4) and Fundação de Amparo a Pesquisa de Minas Gerais (FAPEMIG # APQ-00220-14).
Compliance with Ethical Standards
This work was approved by the University Ethics Committee (CAAE-09135912.6.0000.5149).
Nothing to disclose.
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